An electrochemical immunosensor based on a nano-ceria integrated microfluidic chip for interleukin-8 biomarker detection.

Interleukin-8 (IL8) is an important cytokine that plays a significant role in tumor growth and angiogenesis across various malignant tumors, including oral squamous cell carcinoma (OSCC). It is an important biomarker for oral cancer; therefore, its early and accurate detection in bodily fluid reduces morbidity and mortality rates in cancer patients. The work presents the development of a label-free microfluidic miniaturized electrochemical immunosensor for IL8 biomarker detection at low concentration in saliva samples.

Gut microbiota derived short-chain fatty acids in physiology and pathology: An update.

Short-chain fatty acids (SCFAs) are essential molecules produced by gut bacteria that fuel intestinal cells and may also influence overall health. An imbalance of SCFAs can result in various acute and chronic diseases, including diabetes, obesity and colorectal cancer (CRC). This review delves into the multifaceted roles of SCFAs, including a brief discussion on their source and various gut-residing bacteria.

Trimethylamine N-oxide detection by electrochemical sensor based on screen printed electrode modified with molecularly imprinted polypyrrole-molybdenum(III) sulfide nanosheets.

Trimethylamine N-oxide (TMAO) is a gut metabolite produced by dietary L-carnitine and choline metabolism. Its altered level in the serum has been implicated in human health and diseases such as colorectal cancer, chronic kidney diseases, cardiovascular diseases, etc. Early detection of TMAO in body fluids has been presumed to be significant in understanding the pathogenesis and treatment of many diseases.

4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS Nanosheet-Modified Molecularly Imprinted Biopolymer.

One of the gut-derived uremic toxins 4-ethylphenyl sulfate (4-EPS) exhibits significantly elevated plasma levels in chronic kidney diseases and autism, and its early quantification in bodily fluids is important. Therefore, the development of rapid and sensitive technologies for 4-EPS detection is of significant importance for clinical diagnosis. In the current work, the synthesis of a molecularly imprinted biopolymer (MIBP) carrying 4-EPS specific cavities only using the biopolymer polydopamine (PDA) and molybdenum disulfide (MoS) nanosheets has been reported.

Excellent Adsorption of Lead (II) and Chromium (VI) from Water Using Zwitterions (-NH and -COO) Functionalized Nano Lanthanum Oxide: Kinetic, Isotherm, Thermodynamic, and Surface Mechanism.

Zwitterion amino acid l-cysteine functionalized lanthanum oxide nanoparticles (l-Cyst-LaO NPs) have been synthesized for the first time with lanthanum acetate as the precursor, NHOH as the base, and l-cysteine as the functionalized mediator. The typical size of l-Cyst-LaO NPs was obtained in the range of 15-20 nm from the TEM technique. A cytotoxicity test of l-Cyst-LaO NPs was performed in Raw 264.

Electrochemically microplastic detection using chitosan-magnesium oxide nanosheet.

Microplastics, an invisible threat, are emerging as serious pollutants that continuously affect health by interrupting/contaminating the human cycle, mainly involving food, water, and air. Such serious scenarios raised the demand for developing efficient sensing systems to detect them at an early stage efficiently and selectively. In this direction, the proposed research reports an electrochemical hexamethylenetetramine (HMT) sensing utilizing a sensing platform fabricated using chitosan-magnesium oxide nanosheets (CHIT-MgO NS) nanocomposite.

Granular Hemostatic Composite of Alginate, Calcium, and Zinc for Rapid and Effective Management of Post-Traumatic Hemorrhage.

Post-traumatic hemorrhage, which can result from accidents or battlefield injuries, is a significant global concern due to the high prehospital mortality rate. Substantial efforts have been made to develop hemostatic agents that can effectively reduce hemorrhage in the immediate aftermath of a traumatic event. The present study investigated the potential efficacy of Ca and Zn supplemented sodium alginate-based dry hemostatic particles (SA-CZ DHP) to manage excessive blood loss or post-traumatic hemorrhage.

Nano-modified screen-printed electrode-based electrochemical immunosensors for oral cancer biomarker detection in undiluted human serum and saliva samples.

This proposed work reports the development of in-house made conductive ink-based screen-printed electrodes (SPEs) for label-free detection of oral cancer biomarkers. Carbon ink synthesis includes graphite powder, gum arabic, and water. The selectivity test of the fabricated SPE involves immobilizing antibodies specific to biomarkers and challenges with redox-active interference, other serum molecules, and non-target biomarkers.

Fabrication of Mesoporous Silica Nanoparticle-Decorated Graphene Oxide Sheets for the Effective Removal of Lead (Pb) from Water.

Mesoporous silica nanoparticle-decorated graphene oxide nanosheets (MSiO-GO) were synthesized and characterized for the active removal of lead (Pb) from the water. MSiO NPs were prepared via an ultrasonication method using tetraethyl orthosilicate (TEOS), and GO sheets were obtained via a modified Hummers' method. X-ray diffraction, UV-vis spectroscopy, Fourier transform infrared spectroscopy, and energy dispersive X-ray spectroscopy specified the composition of MSiO NPs and GO sheets.

Polyvinyl alcohol-derived-carbon quantum dots based fluorometric "On-Off" probe for moxifloxacin detection in milk and egg samples.

Unconditional use of antibiotics triggered the process of bacterial resistance and causes major health problems. Nowadays, antibiotics majorly used in animals not only for infection treatment but also as mass promotor. The excess amount of antibiotics residue in animal derived foods which accelerate antibiotic resistance (ABR).

Investigation of Luliconazole-Loaded Mucoadhesive Electrospun Nanofibers for Anticandidal Activity in the Management of Vaginal Candidiasis.

In this study, we fabricated and evaluated luliconazole-loaded electrospun nanofibers for anticandidal activity in the management of vaginal candidiasis. Polycaprolactone (PCL)/gelatin nanofibers were designed by the electrospinning technique, and the Box-Behnken design (BBD) was adopted for optimization to get tailored fibers. The luliconazole (LCZ) drug was mixed into different concentrations (2.

Development of aptasensor for chlorpyrifos detection using paper-based screen-printed electrode.

Novel Carbon quantum dots-graphite composite ink-based Screen-printed electrodes (CQDs/SPEs) were used to assemble a highly sensitive electrochemical aptasensor against chlorpyrifos (CPF). The aptasensor showed a broad linear range from 1 pM (0.445 ng/ml) to 500 nM (0.

Enhanced Electrochemical Biosensing of the Sp17 Cancer Biomarker in Serum Samples via Engineered Two-Dimensional MoS Nanosheets on the Reduced Graphene Oxide Interface.

In the present investigation, we reported a label-free and highly effective immunosensor for the first time employing a nanostructured molybdenum disulfide nanosheets@reduced graphene oxide (nMoS NS@rGO) nanohybrid interface for the determination of sperm protein 17 (Sp17), an emerging cancer biomarker. We synthesized the nMoS NS@rGO nanohybrid using a one-step hydrothermal technique and then functionalized it with 3-aminopropyltriethoxysilane (APTES). Furthermore, the anti-Sp17 monoclonal antibodies were covalently attached to the APTES/nMoS NS@rGO/indium tin oxide (ITO) electrode utilizing 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide--hydroxy succinimide (EDC-NHS) coupling chemistry.

Graphene oxide-MnOnanocomposites for advanced electrochemical biosensor for fumonisin B1 detection.

Occurrence of mycotoxins in food samples threat to its safety issue due to the presence of high toxicity and carcinogenic behavior, thus requiring highly sensitive and selective detection. Herein, the trimanganese tetraoxide (MnO) nanoparticles in combination with graphene oxide (GO) nanocomposite were used to enhance the electrochemical performance for fabrication of electrochemical biosensor for fumonisin B1 (FB1) detection. The various characterization tools were used to validate the fabrication of GOMnOnanocomposites.

Electrochemical Detection of by Amine Functionalized Biocompatible Gadolinium Oxide Nanoparticles.

Herein, we report the biocompatible amine-functionalized gadolinium oxide nanoparticles (GdO NPs) for the possibility of electrochemical detection of () cells. The microwave irradiation process is applied to synthesize GdO NPs. The amine (NH) functionalization is carried out via overnight stirring with 3(Aminopropyl)triethoxysilane (APTES) at 55 °C.

FRET Based Biosensor: Principle Applications Recent Advances and Challenges.

Förster resonance energy transfer (FRET)-based biosensors are being fabricated for specific detection of biomolecules or changes in the microenvironment. FRET is a non-radiative transfer of energy from an excited donor fluorophore molecule to a nearby acceptor fluorophore molecule. In a FRET-based biosensor, the donor and acceptor molecules are typically fluorescent proteins or fluorescent nanomaterials such as quantum dots (QDs) or small molecules that are engineered to be in close proximity to each other.

Biocompatible epoxysilane substituted polymer-based nano biosensing platform for label-free detection of cancer biomarker SP17 in patient serum samples.

Herein, we report the results of the studies relating to developing a simple, sensitive, cost-effective, and disposable electrochemical-based label-free immunosensor for real-time detection of a new cancer biomarker, sperm protein-17 (SP17), in complex serum samples. An indium tin oxide (ITO) coated glass substrate modified with self-assembled monolayers (SAMs) of 3-glycidoxypropyltrimethoxysilane (GPTMS) was functionalized via covalent immobilization of monoclonal anti-SP17 antibodies using EDC(1-(3-(dimethylamine)-propyl)-3-ethylcarbodiimide hydrochloride) - NHS (N-hydroxy succinimide) chemistry. The developed immunosensor platform (BSA/anti-SP17/GPTMS@SAMs/ITO) was characterized via scanning electron microscopy (SEM), atomic force microscopy (AFM), contact angle (CA), Fourier transform infrared (FT-IR) spectroscopic, and electrochemical techniques such as cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) techniques.

Recent trends in nanocomposite packaging films utilising waste generated biopolymers: Industrial symbiosis and its implication in sustainability.

Uncontrolled waste generation and management difficulties are causing chaos in the ecosystem. Although it is vital to ease environmental pressures, right now there is no such practical strategy available for the treatment or utilisation of waste material. Because the Earth's resources are limited, a long-term, sustainable, and sensible solution is necessary.

Gold@Carbon Quantum Dots Nanocomposites Based Two-In-One Sensor: A Novel Approach for Sensitive Detection of Aminoglycosides Antibiotics in Food Samples.

Antibiotics are life-saving drugs for humans, but their unwanted use leads to antibacterial resistance (ABR) and causes serious health problems. The excess of these antibiotics entered to the food chain and caused food contamination. Here, Au@CQDs nanocomposites (NCs) was used as a two-in-one sensor to detect two antibiotics.

Amine Functionalized Gadolinium Oxide Nanoparticles-Based Electrochemical Immunosensor for Cholera.

Herein, we report the synthesis and functionalization of gadolinium oxide nanoparticles (GdO NPs) to fabricate a highly efficient immunosensor for the detection of toxin (CT). GdO NPs were produced in a straightforward manner utilizing the microwave irradiation technique using a domestic microwave oven. X-ray diffraction, transmission electron microscopy, and spectroscopic techniques were used to characterize the structural and physical aspects of GdO NPs.

Facile synthesis of carbon dots via pyrolysis and their application in photocatalytic degradation of rhodamine B (RhB).

Carbon Quantum dot (CQDs) is one of the newest materials in carbon-based nanomaterials. It is pertinent to study the synthesis and the application of these carbon dots. Here we have studied the effect of precursor on the optical, morphological, and photocatalytic properties of CQDs.