Publications by authors named "Pratima Prabala"
Article Synopsis
- The study investigates the branching pattern of coronary arteries in humans, known as coronary dominance, and aims to understand its genetic regulation, which has been poorly understood due to challenges in studying human heart development.
- By analyzing data from 61,043 participants in the VA Million Veteran Program, researchers identified a moderate heritability of 27.7% for coronary dominance and discovered ten significant genetic loci, particularly near a chemokine-related region.
- The findings suggest that the gene in question plays a crucial role in the development of coronary artery patterns, as experiments in mice showed altered artery development when this gene was reduced, indicating potential targets for future medical treatments related to coronary artery conditions.
