Interaction of VO-hydrazonates with lysozyme.

Vanadium compounds (VCs) exhibit a broad range of pharmacological properties, with their most significant medical applications being in the treatment of cancer and diabetes. The therapeutic effects and mode of action of VCs may be associated with their ability to bind proteins and, consequently, understanding the VC-protein interaction is of paramount importance. Among the promising VCs, the VO complex with the aroylhydrazone furan-2-carboxylic acid ((3-ethoxy-2-hydroxybenzylidene)hydrazide, hereafter denoted as VC1), deserves attention, since it exhibits cytotoxicity against various cancer cell lines, including HeLa.

Insights into the Theranostic Activity of Nonoxido V: Lysosome-Targeted Anticancer Metallodrugs.

Developing new anticancer agents can be useful, with the ability to diagnose and treat cancer worldwide. Previously, we focused on examining the effects of nonoxidovanadium(IV) complexes on insulin mimetic and cytotoxicity activity. In this study, in addition to the cytotoxic activity, we evaluated their bioimaging properties.

Monomeric copper(II) complexes with unsymmetrical salen environment: Synthesis, characterization and study of biological activities.

Three new ONNO-donor tetradentate unsymmetrical salen ligands were synthesized by using o-phenyl diamine with substituted salicylaldehydes followed by a two-step reaction methodology. These three ligands by reaction with Cu(OAc).4HO produced three new monomeric Cu(II) complexes, [Cu(L)] (1-3).

Recent advancements of fluorescent tin(IV) complexes in biomedical molecular imaging.

In the last few years, tin(IV) complexes have emerged as very attractive candidates in the field of molecular imaging due to their unique photophysical properties. Despite the few reviews published to date covering the chemistry of organotin and tin complexes and their cytotoxic potential, there are no reviews devoted to their live cell imaging properties. Therefore, this feature article summarizes the discussion of the fundamental photophysical properties of fluorescent tin metal complexes focusing on their recent advances in "biomedical molecular imaging".

LVO-Ethyl Maltol-Based Metallodrugs (L = Tridentate ONO Ligands): Hydrophobicity, Hydrolytic Stability, and Cytotoxicity via ROS-Mediated Apoptosis.

Four new oxidovanadium [VOL(ema)] complexes (-) have been synthesized using tridentate binegative ONO donor ligands HL [HL: ()--(2-hydroxybenzylidene)furan-2-carbohydrazide; HL: ()--(4-(diethylamino)-2-hydroxybenzylidene)thiophene-2-carbohydrazide; HL: ()-2-(4-(diethylamino)-2-hydroxybenzylideneamino)-4-methylphenol; HL: ()-2-(3-ethoxy-2-hydroxybenzylideneamino)-4-methylphenol] and ethyl maltol (Hema) as a bidentate uninegative coligand and characterized by CHNS analysis, IR, UV-vis, NMR, and HR-ESI-MS methods. The structures of , , and are confirmed by single-crystal X-ray analysis. The hydrophobicity and hydrolytic stability of the complexes are tested using NMR and HR-ESI-MS and correlated with their observed biological activities.

Mitochondria-Targeted Luminescent Organotin(IV) Complexes: Synthesis, Photophysical Characterization, and Live Cell Imaging.

Five fluorescent ONO donor-based organotin(IV) complexes, (), were synthesized by the one-pot reaction method and fully characterized spectroscopically including the single-crystal X-ray diffraction studies of . Detailed photophysical characterization of all compounds was performed. All the compounds exhibited high luminescent properties with a quantum yield of 17-53%.

Recent advancements on decarbonylation reactions assisted by Ru-complexes: Synthetic and mechanistic approach.

This frontier article covers the recent advancements in ruthenium complex catalysed decarbonylation reactions of different types of carbonyl compounds and provides a direction towards the mechanistic understanding. The mechanistic pathways provide new strategies for the use of appropriate ruthenium-catalysts, increase the substrate scope, and help in the synthesis of new complexes having multiple functionalities. The content of the article is categorized on the basis of the use of substrates.

Dithiocarbazate based oxidomethoxidovanadium(V) and mixed-ligand oxidovanadium(IV) complexes: Study of solution behavior, DNA binding, and anticancer activity.

In this work, one oxidomethoxidovanadium(V) [VO(L)(OMe)] (1) and two mixed-ligand oxidovanadium(IV) [VO(L)(phen)] (2), and [VO(L)(bipy)] (3) complexes have been synthesized using a tridentate bi-negative ONS donor dithiocarbazate as main ligand, HL [where, HL = S-benzyl-3-(2-hydroxy-3-ethoxyphenyl)methylenedithiocarbazate] along with 1,10-phenanthroline (phen) (for 2) and 2,2'-bipyridine (bipy) (for 3) as co-ligands. The ligand and complexes have been characterised by FT-IR, UV-vis, NMR, and HR-ESI-MS techniques. Distorted square pyramidal for 1, and distorted octahedral geometry for 2 and 3 was confirmed by single crystal X-ray crystallography.