Challenges in diagnosis and treatment of pediatric psoriasis and atopic dermatitis.

Psoriasis and atopic dermatitis are prevalent skin conditions affecting many children, each driven by distinct immunological pathways. Psoriasis is characterized by the activation of the Th17/IL-17/IL-23 axis, leading to rapid skin cell proliferation and the formation of thick, scaly plaques. In contrast, atopic dermatitis is primarily driven by the Th2/IL-4/IL-13 pathway, resulting in intense itching and disruption of the skin's protective barrier.

Trace elements in psoriasis presentation and treatment.

This systematic literature review examines the relationship between psoriasis and trace metals to elucidate the pathogenesis of this condition, and to explore their potential use as a new route of treatment. Searches were primarily conducted in three databases: PubMed, Scopus, and Embase. The initial search resulted in over 100 articles which were manually assessed by the researchers to determine relevancy.