Publications by authors named "Pratik A Ambekar"
Histotripsy-induced bactericidal activity correlates to size of cavitation cloud in vitro.
IEEE Trans Ultrason Ferroelectr Freq Control
October 2024
Article Synopsis
- * Researchers aim to use therapeutic ultrasound, specifically a technique called histotripsy, as a noninvasive way to destroy bacteria within these abscesses.
- * The study found a strong link between the size of the cavitation cloud produced during histotripsy and the effectiveness of bacterial inactivation, indicating promising potential for this ultrasound method.
Objective: Bacterial loads can be effectively reduced using cavitation-mediated focused ultrasound, or histotripsy. In this study, gram-negative bacteria (Escherichia coli) in suspension were used as model bacteria to evaluate the effectiveness of two regimens of histotripsy treatments: cavitation histotripsy (CH) and boiling histotripsy (BH).
Methods: Ten-milliliter volumes of Escherichia coli were treated at different negative focal pressure amplitudes and over time periods up to 40 min.