Novel azole-sulfonamide conjugates as potential antimicrobial candidates: synthesis and biological assessment.

Azole and sulfonamide molecular frameworks are endowed with potent antimicrobial activity. A series of azole-sulfonamide conjugates were synthesized using click reaction of N-propargylated imidazole with azide of sulfonamide and its antimicrobial efficacy was evaluated. The compounds , and displayed promising antibacterial activities, better than the standards sulfonamide and norfloxacin.