Fit-for-Purpose Ki-67 Immunohistochemistry Assays for Breast Cancer.

New therapies are being developed for breast cancer, and in this process, some "old" biomarkers are reutilized and given a new purpose. It is not always recognized that by changing a biomarker's intended use, a new biomarker assay is created. The Ki-67 biomarker is typically assessed by immunohistochemistry (IHC) to provide a proliferative index in breast cancer.

Predictors of Outcome in Mammary Adenoid Cystic Carcinoma: A Multi-Institutional Study.

Mammary adenoid cystic carcinoma (ACC) is a rare subtype of breast cancer with a favorable prognosis. Here we report on predictors of outcome based on a detailed morphologic review and analysis of 108 mammary ACC. Sixty-four tumors (59.

Fine needle aspiration of renal cortical lesions in adults.

The role of fine needle aspiration (FNA) biopsy of renal cortical lesions was controversial in the past because the result of the FNA did not affect clinical management. All renal cortical lesions, except metastasis, were subject to surgical resection. However, with the advances in neoadjuvant targeted therapies, knowledge of the renal cortical tumor histological subtype is critical for tailoring clinical trials and follow-up strategies.

Diagnostic pitfalls in fine needle aspiration biopsy of the spleen.

Fine needle aspiration (FNA) of the spleen is rarely performed, due to fear of procedure complications. The objective of this study is to review the cytologic diagnoses of aspiration biopsy of the spleen performed in a cancer center. Archival material (9-year period) was reviewed and correlated with histologic and ancillary test results, when available.

Vaginal solitary fibrous tumor: a case report with recurrence after incomplete excision.

Objective: Primary solitary fibrous tumors (SFTs) of the female genital tract are exceedingly rare. We report a spindle cell tumor of the vagina with features consistent with a SFT in a 52-year-old woman.

Materials And Methods: The original tumor was studied with the appropriate panel of immunohistochemical stains.

Fine needle aspiration biopsy of primary mucinous carcinoma of the skin: a case report.

Background: Primary mucinous carcinoma of the skin is a rare neoplasm of sweat gland origin. To date there are only 2 case reports in English describing its features on fine needle aspiration biopsy (FNAB). We describe an additional case and review the literature regarding this entity.

Immunophenotypic diversity of endometrial adenocarcinomas: implications for differential diagnosis.

Many endometrial adenocarcinomas, particularly those of endometrioid type, express estrogen receptors (ERs), progesterone receptors (PRs), and vimentin. This typical immunophenotype is frequently considered a standard against which others are compared when immunohistochemistry is used for differential diagnosis. We tested large numbers of endometrial cancers, enriched for high-grade tumors, to determine whether this reported immunophenotype was valid and whether expression differences between types of endometrial carcinoma could be exploited for diagnostic purposes.

Fine-needle aspiration cytology of mammary adenomyoepithelioma: a study of 12 patients.

Background: Adenomyoepithelioma (AME) of the breast is a rare neoplasm that is characterized by a biphasic proliferation of epithelial and myoepithelial cells. Incomplete excision of this lesion is associated with a greater risk of recurrence. Although the histology of AME is well characterized, its cytomorphology has not been assessed in a large series.

Grg1 acts as a lung-specific oncogene in a transgenic mouse model.

Groucho proteins are transcriptional corepressors that are recruited to gene regulatory regions by numerous transcription factors. Long isoforms, such as Grg1, have all the domains of the prototype Drosophila Groucho. Short Groucho proteins, such as Grg5, have only the amino-terminal Q and G/P domains.

Perivascular epithelioid cell tumor of the orbit: a case report and review of the literature.

We present a unique case of a perivascular epithelioid cell tumor (PEComa) in the orbit of a 9-year-old female patient. The entity of PEComas has been described only recently. Characteristic histologic features and an immunohistochemical profile of negativity for epithelial markers and positivity for melanogenesis-related markers define the tumors.

Precursor B-cell lymphoblastic lymphoma of the ovaries: an immunohistochemical study and review of the literature.

A 46-year-old woman presented with increasing abdominal girth. Investigations revealed bilateral ovarian tumors but no evidence of systemic disease. A total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed.

Primary extranodal marginal zone B-cell lymphoma of MALT type of the endometrium.

Background: Only one case of primary extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the endometrium has been previously reported.

Case: A 65-year old patient presented with postmenopausal bleeding. She was found to have endometrial polyps.

Skp2 gene copy number aberrations are common in non-small cell lung carcinoma, and its overexpression in tumors with ras mutation is a poor prognostic marker.

Purpose: Skp2 plays a critical role in cell cycle progression, especially at the G(1)-S transition, putatively through its control of several cell cycle regulator proteins. The Skp2 gene is located on a region of chromosome 5p that is commonly overrepresented in lung cancer. The present study aimed to evaluate Skp2 abnormalities and their prognostic value in non-small cell lung cancer (NSCLC).

Juvenile xanthogranuloma of the nose.

Juvenile xanthogranuloma is a type of non-Langerhans cell histiocytosis that occurs most frequently in infants and children. It is usually asymptomatic and can present as either a cutaneous or extracutaneous lesion. The present case is believed to be the first reported in the English literature of juvenile xanthogranuloma presenting as an ulcerated bleeding lesion on the dorsum of the nose.