Publications by authors named "Prathik Bandya"
Article Synopsis
- A new diagnostic test using whole blood gene analysis may help identify encephalopathic babies at risk of poor neurodevelopmental outcomes within 18 months after birth.
- Researchers performed next-generation sequencing on blood samples from 45 encephalopathic infants, identifying 855 genes with significant differences between those with good and adverse outcomes.
- The findings suggest that transcriptomic profiling could enhance risk assessment in neonatal encephalopathy and reveal potential new treatments for protecting brain health.
Unlabelled: Although therapeutic hypothermia (TH) is the standard of care for hypoxic ischaemic encephalopathy in high-income countries, the safety and efficacy of this therapy in low-income and middle-income countries (LMICs) is unknown. We aimed to describe the feasibility of TH using a low-cost servo-controlled cooling device and the short-term outcomes of the cooled babies in LMIC.
Design: We recruited babies with moderate or severe hypoxic ischaemic encephalopathy (aged <6 hours) admitted to public sector tertiary neonatal units in India over a 28-month period.
Background: Therapeutic hypothermia reduces death and disability after moderate or severe neonatal encephalopathy in high-income countries and is used as standard therapy in these settings. However, the safety and efficacy of cooling therapy in low- and middle-income countries (LMICs), where 99% of the disease burden occurs, remains unclear. We will examine whether whole body cooling reduces death or neurodisability at 18-22 months after neonatal encephalopathy, in LMICs.
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