Publications by authors named "Prathap K Simhadri"
Article Synopsis
- Diagnosing infections in patients with autosomal dominant polycystic kidney disease (ADPKD) is challenging, and 18-fluorodeoxyglucose positron-emission tomography-computed tomography (F-FDG PET-CT) is often recommended, though its accuracy is debated.
- Through a meta-analysis of seven studies, researchers evaluated the diagnostic performance of F-FDG PET-CT, finding a pooled sensitivity of 82.6% and specificity of 77.6% for identifying kidney and hepatic cyst infections.
- Overall, results indicate that F-FDG PET-CT shows strong diagnostic performance, making it a valuable tool for detecting renal and hepatic cyst infections in patients with ADPKD
Renal insufficiency is a risk factor for cardiac implantable electronic device (CIED) infection. : A comprehensive search was conducted from multiple electronic databases to identify studies. Using the random effects model, we calculated the pooled rates of CIED infection and their 95% confidence intervals.
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- The study discusses the rise of renal cell carcinoma (RCC) and the importance of accurate subtype classification for diagnosis and treatment, which can be enhanced through deep learning technologies.
- A meta-analysis was performed on 347 studies, ultimately including 13 retrospective studies with 5340 patients, to evaluate the diagnostic performance of deep neural networks (DNN) in detecting RCC subtypes and predicting patient survival.
- Results showed that DNN achieved a high accuracy of 92.3% for overall diagnosis, 93.5% for subtype detection, and 81% for survival predictions, indicating strong potential for AI in improving RCC clinical outcomes.
People with sickle cell disease experience a high incidence of chronic kidney disease and end-stage kidney disease, secondary to tubular and glomerular effects of vaso-occlusion-induced hypoxia. Because of concerns of suboptimal kidney function, sickle cell donors are usually not considered for kidney donation, even if the rest of the parameters are acceptable for organ donation. A significant gap exists between the number of organ donors and the number of candidates waiting for a kidney transplant in the United States.
View Article and Find Full Text PDFBoth C-anti-neutrophil cytoplasmic antibody (ANCA) and P-ANCA vasculitis were reported to be associated with COVID-19 infection. The ideal management of COVID-19-associated ANCA vasculitis is unclear, as the experiences were limited to case reports. We presented a case of COVID-19-associated C-ANCA vasculitis, successfully treated with steroids and rituximab therapy without any significant adverse reactions.
View Article and Find Full Text PDF: Patients with infective endocarditis (IE) are more susceptible to acute kidney injury (AKI). The presence of AKI increases in-hospital complications in these patients. : The 2016-2020 National Inpatient Sample (NIS) database consisting of adult admissions with IE and AKI was utilized.
View Article and Find Full Text PDFCystinuria is an autosomal recessive disorder associated with defective proximal tubular reabsorption of divalent amino acids. It leads to increased cystine, ornithine, lysine, and arginine excretion in the urine. Cystine is insoluble in physiological pH, and cystinuria leads to crystalluria and nephrolithiasis.
View Article and Find Full Text PDFSodium-glucose cotransporter-2 inhibitors (SGLT2i) are a relatively newer class of medications, approved by the U.S. Food and Drug Administration in 2013 to treat type 2 diabetes mellitus.
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