Pediatric and adolescent pheochromocytoma: clinical presentation and outcome of surgery.

Objectives: To describe the clinical presentation and outcome of surgery in children with pheochromocytoma in a tertiary care hospital in India.

Methods: Clinical records of 24 children who were operated between January 1990 and January 2011 were reviewed. The diagnosis of familial disease was established based on clinical examination and follow-up events.

Medullary thyroid cancer: clinico-pathological profile and outcome in a tertiary care center in North India.

Background: Recent advances in genetic screening have ushered in a new era in diagnosis and management of medullary thyroid cancer (MTC). However, the same is not true for a resource-poor country, where clinicians are still struggling to diagnose and adequately manage this relatively uncommon thyroid malignancy. We hereby present our experience of managing MTC at a tertiary care referral center in North India.

Glutathione S-transferase M1 and T1 polymorphism and response to neoadjuvant chemotherapy (CAF) in breast cancer patients.

Purpose: Response to neoadjuvant chemotherapy (NACT) for breast cancer patients cannot be predicted; however, polymorphism of the glutathione S-transferase genes GSTM1 and GSTT1 can modify the response to chemotherapy. The aim of this study was to establish whether there is an association between the polymorphism of GSTM1 and GSTT1 and response to NACT.

Methods: The subjects of this study were 45 patients with locally advanced breast cancer (LABC), who received the cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) regimen as NACT.

Two port laparoscopic ventral hernia mesh repair: an innovative technical advancement.

Ventral hernia is a common surgical problem. The traditional open surgical repair has the disadvantage of excessive morbidity, long hospital stay and high recurrence rates. Laparoscopic ventral hernia repair (LVHR) is gaining acceptance but there is no standardized technique for the repair of these hernias.

Size of the tumor and pheochromocytoma of the adrenal gland scaled score (PASS): can they predict malignancy?

Background: Size can predict malignancy in adrenocortical tumors, but the same extrapolation for pheochromocytomas (PCC) is controversial. The goal of this study was to find a correlation between the tumor size and malignant potential of PCC and determine whether the "Pheochromocytoma of the adrenal gland scaled score" (PASS) proposed by Thompson can be applied to predict malignancy.

Methods: A retrospective analysis of patients with PCC operated on from 1991 to 2007 revealed 98 PCC removed from 93 patients.

Placental lead-induced oxidative stress and preterm delivery.

It has been reported that impaired oxidant/antioxidant status is involved in a variety of pregnancy complications. To elucidate the possible free radical mediated mechanism of preterm delivery due to lead exposure by determining the placental lead level and oxidant/antioxidant status in women with the preterm and full-term deliveries. Twenty-nine women with preterm deliveries (gestational age 28-37 weeks) and 31 women with full-term deliveries (gestational age >37 weeks) attending a local hospital of Lucknow, India were recruited.

Inflammatory variant of a well-differentiated retroperitoneal liposarcoma: case report of a rare giant variety.

Inflammatory liposarcoma is a rare variant of a well-differentiated liposarcoma (WDLPS). We present a case of a 37 years old male who had a giant variety of this inflammatory WDLPS. CT scan revealed a large abdomino-pelvic mass abutting the left kidney and pushing the IVC, Aorta and the left ureter across the midline.

Laparoscopic management of gallstone presenting as obstructive gangrenous appendicitis.

We present an unusual case of a 55-year-old man with symptoms of recurrent appendicitis. Laparoscopy revealed a 1.5 cm gallstone impacted at the base of the appendix, leading to gangrenous appendicitis.

Giant pseudocyst of the anterior abdominal wall following mesh repair of incisional hernia: a rare complication managed laparoscopically.

Unlabelled: Giant pseudocyst formation of the anterior abdominal wall, following on-lay polypropylene mesh repair for incisional hernia is an under reported complication. We report an unusual case of a 56-year-old female who underwent a polypropylene mesh repair of incisional hernia 2 years back. Subsequently she developed a giant pseudocyst of the anterior abdominal wall, which was occupying the whole of the abdomen from the xiphisternum to the pubic bone, and over both the flanks.