Digital Twin-Assisted Lightpath Provisioning and Nonlinear Mitigation in C+L+S Multiband Optical Networks.

Multiband (MB) optical transmission targets increasing the capacity of operators' optical transport networks. However, nonlinear impairments (NLI) affect each optical channel in the C+L+S bands differently, and, therefore, the routing and spectrum assignment (RSA) problem needs to be complemented with fast and accurate tools to consider the quality of transmission (QoT) within the provisioning process. This paper proposes a digital twin-assisted approach for lightpath provisioning to provide a complete solution for the RSA problem that ensures the required QoT in MB optical networks.

Galactinol synthase 4 requires sulfur assimilation pathway to provide tolerance towards arsenic stress under limiting sulphur condition in Arabidopsis.

Heavy metalloid stress such as arsenic (As) toxicity and nutrient imbalance constitute a significant threat to plant productivity and development. Plants produce sulfur (S)-rich molecules like glutathione (GSH) to detoxify arsenic, but sulfur deficiency worsens its impact. Previous research identified Arabidopsis thaliana ecotypes Koz2-2 (tolerant) and Ri-0 (sensitive) under low-sulfur (LS) and As(III) stress.

Examining structure-activity relationships of ManNAc analogs used in the metabolic glycoengineering of human neural stem cells.

This study defines biochemical mechanisms that contribute to novel neural-regenerative activities we recently demonstrated for thiol-modified ManNAc analogs in human neural stem cells (hNSCs) by comparing our lead drug candidate for brain repair, "TProp," to a "size-matched" N-alkyl control analog, "But." These analogs biosynthetically install non-natural sialic acids into cell surface glycans, altering cell surface receptor activity and adhesive properties of cells. In this study, TProp modulated sialic acid-related biology in hNSCs to promote neuronal differentiation through modulation of cell adhesion molecules (integrins α6, β1, E-cadherin, and PSGL-1) and stem cell markers.

Global proteomics reveals pathways of mesenchymal stem cells altered by Mycobacterium tuberculosis.

Mycobacterium tuberculosis (M. tb) has a remarkable ability to persist inside host cells. Several studies showed that M.

Safety and Phosphate-Binding Capacity of Oxylanthanum Carbonate in Healthy Volunteers.

Despite the widespread use of currently available serum phosphate management options, elevated serum phosphate is common in patients with end-stage kidney disease on dialysis. Characteristics of currently available phosphate binders that lead to poor patient experiences such as large drug volume size of required daily medication (e.g.

Essential strategies for the detection of constitutive and ligand-dependent Gi-directed activity of 7TM receptors using bioluminescence resonance energy transfer.

The constitutive (ligand-independent) signaling of G protein-coupled receptors (GPCRs) is being increasingly appreciated as an integral aspect of their function; however, it can be technically hard to detect for poorly characterized, e.g. orphan, receptors of the cAMP-inhibitory Gi-coupled (GiPCR) family.

Repercussion of SARS-CoV-2 on the Sexual Function in Males Updated Review.

SARS-CoV-2, also called coronavirus causes SARS-CoV-2 or severe acute respir-atory syndrome, a highly transmissible disease that has rapidly spread worldwide, straining healthcare systems and leading to a substantial number of fatalities. Interestingly, SARS-CoV-2 has revealed a gender difference, with males dying at a greater rate and with more severe cases than women. It's worth noting that the male reproductive system might be par-ticularly susceptible to damage during periods of moderate to severe sickness, which has been linked to cases of orchitis and erectile dysfunction.

Are Mucinous Carcinomas of the Breast Hard on Elastography?

Mucinous carcinomas are a rare type of invasive breast carcinoma characterized by large quantities of extracellular mucin on histopathological examination. These tumors can be easily missed or misdiagnosed. Due to large quantities of mucin, these tumors are presumed to be "soft" masses.

Tissue engineered decellularized bovine pericardium as prosthetic material in paediatric cardiac surgery.

Aim: To evaluate the short-term outcomes of Tissue Engineered Decellularized Bovine pericardium (Synkroscaff®) in congenital heart surgery as a prosthetic material.

Methodology: This is a prospective observational cohort study. SynkroScaff® was used as prosthetic material in cohort of successive patients under 18 years of age requiring cardiac surgery for congenital heart diseases.

Colours of India: Uniting Endocrinologists in Fitness and Friendship.

Colours of India is an annual cultural phenomenon that transcends the boundaries of professional conferences, uniting endocrinologists through the universal language of music and dance. Since its inception in 2016, this vibrant event has brought together teams from across India and other participating countries, showcasing diverse dance forms while fostering friendships, promoting wellness, and celebrating cultural diversity within the medical community.

Characteristics and Resource Utilization of Hospitalized Children With Somatic Symptoms.

Objective: To examine patient characteristics and resource utilization of hospitalized children and adolescents with somatic symptom and related disorders (SSRDs).

Patients And Methods: This study included 173 patients who were aged 6 to 18 years and admitted to a single, tertiary academic children's hospital between April 2015 and December 2021 with a diagnosis of an SSRD. Sociodemographic information and clinical features were assessed as outcomes.

Synergistic Multi-Pronged Interactions Mediate the Effective Inhibition of Alpha-Synuclein Aggregation by the Chaperone HtrA1.

Unlabelled: The misfolding, aggregation, and the seeded spread of alpha synuclein (α-Syn) aggregates are linked to the pathogenesis of various neurodegenerative diseases, including Parkinson's disease (PD). Understanding the mechanisms by which chaperone proteins prevent the production and seeding of α-Syn aggregates is crucial for developing effective therapeutic leads for tackling neurodegenerative diseases. We show that a catalytically inactive variant of the chaperone HtrA1 (HtrA1*) effectively inhibits both α-Syn monomer aggregation and templated fibril seeding, and demonstrate that this inhibition is mediated by synergistic interactions between its PDZ and Protease domains and α-Syn.

Klotho protein: a new insight into the pathogenesis of essential hypertension.

Background: Essential hypertension is a most prevalent global health concern. Despite extensive research, the exact mechanisms contributing to essential hypertension remain unclear. Several factors contribute to the pathogenesis of essential hypertension.

Navigating AI: A Quick Start Guide for Healthcare Professionals.

The rapid and nimble growth of artificial intelligence (AI) in healthcare has generated significant excitement among healthcare professionals. The most common question asked by clinicians about AI therefore is: "How do I get started?". We outline a strategic approach for clinicians to integrate AI into their knowledge base, focusing on goal setting, creating a learning roadmap, identifying essential resources, and establishing success metrics.

Time series analysis of uptake and translocation of Cd and expression of transporter genes in nine Andrographis paniculata accessions.

Cadmium is a non-essential and toxic metal. Its presence in plants can have hazardous effects not only on the plants themselves but also on human health after consumption. A time-dependent experiment was conducted on nine accessions of A.

Hydrothermal Stability of Active Sites in Cu-Exchanged Small-Pore Zeolites for the Selective Catalytic Reduction of NO.

Combining operando X-ray absorption spectroscopy (XAS) and computational modelling shows unequivocally the distribution of active species in fresh and hydrothermally aged Cu-CHA and Cu-AEI zeolites during NH-assisted selective catalytic reduction of NO. Four principal species co-exist: (i) Cu cations coordinated to NH, (ii) Cu cations coordinated to the zeolite framework, (iii) solvated Cu cations, and (iv) framework-coordinated Cu species (Cu ) formed upon hydrothermal ageing of the zeolite sample. The Cu species were only observed in the hydrothermally aged zeolite samples and are formed upon the interaction of hydrated Cu cations with extra-framework Al (EFAl) generated during the hydrothermal treatment.

Conduction band photonic trapping band gap reversal of brookite quantum dots using controlled graphitization for tuning a multi-exciton photoswitchable high-performance semiconductor.

Brookite exists as the metastable phase of titania and often mediates the transformation of anatase to rutile. The photocatalytic competence of brookite relative to polymorphs anatase and rutile has generally been considered structurally and energetically unfavourable for reasons that remain largely unknown and unchallenged. However, the process of phase transformation and performance related cooperativity among all three polymorphs has recently unlocked alternative directions for exploring brookite photovoltaics.

Sailing Through Choppy Waters: Management of Medical Oxygen Emergencies During the Second Wave of the COVID-19 Pandemic in India.

During the second wave of COVID-19 pandemic, an increasing number of patients experienced breathlessness, which progressed to acute respiratory distress syndrome, leading to the need for supplemental oxygen therapy and mechanical ventilation. With each passing day, the need for medical oxygen increased and simultaneously medical oxygen reserves in the country were getting depleted. Government agencies deployed multipronged strategies to ensure that the hospitals had an adequate supply of medical oxygen.

A Pilot Study on BRCA1/2 and PI3K Mutations Across Subtypes of Triple Negative Breast Cancer in North Indian Population.

BRCA1/2 are tumor suppressor genes which regulate the DNA repair mechanism. Mutations in BRCA1/2 may increase the risk of breast cancer in patients. In the present study frequency of BRCA1/2 mutations in triple negative breast cancer (TNBC) patients was assessed and correlated with molecular subtypes of TNBC.