Synthesis and antibacterial potential of novel thymol derivatives against methicillin-resistant and pathogenic bacteria.

The increasing threat of antibiotic resistance has created an urgent need for new antibacterial agents, particularly plant-based natural compounds and their derivatives. Thymol, a natural monoterpenoid phenolic compound derived from , is known for its aromatic and therapeutic properties, including antibacterial activity. This study focuses on synthesizing dihydropyrimidinone and dihydropyridine derivatives of thymol and exploring their antibacterial properties.

Biotransformation of Geraniol to Geranic Acid Using Fungus IIIMF4011.

Geraniol is an important component in essential oils of aromatic plants such as lemongrass, rosa grass, and many others. It can be converted to different high-value products by using microbes/enzymes. The present study aims at the isolation and screening of microbes showing efficient production of geranic acid (a high-value product) from geraniol (a low-value monoterpene).

Medicinal plants traditionally used in health care practices by inhabitants of Paddar region of Jammu and Kashmir, India.

Ethnopharmacological Relevance: The present study is the first quantitative assessment of ethno-medicinal plants of Paddar region of Jammu and Kashmir.

Aim Of The Study: The study aimed to document the relative importance of medicinal plants used in human ailments by the villagers in the Paddar region of Jammu and Kashmir, India.

Material And Methods: Data were collected from 132 informants (72 male and 60 female) through semi structured interviews and group discussions.

Trilliumosides K and L, two novel steroidal saponins from rhizomes of , as potent anti-cancer agents targeting apoptosis in the A-549 cancer cell line.

Two novel steroidal saponins, trilliumosides K () and L (), were isolated from the rhizomes of led by bioactivity-guided phytochemical investigation along with seven known compounds: govanoside D (), protodioscin (), borassoside E (), 20-hydroxyecdysone (), 5,20-hydroxyecdysone (), govanic acid (), and diosgenin (). The structure of novel compounds 1-2 was established using analysis of spectroscopic data including 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-ESI-MS) data. All isolated compounds were evaluated for cytotoxic activity against a panel of human cancer cell lines.

Costunosides A-C: cytotoxic sesquiterpene lactones from the rhizomes of Falc.

Three new eudesmane type rare sesquiterpene lactone galactosides, costunosides A-C ( were isolated from the rhizomes of along with ten known compounds (). Costunosides A-C ( are the first example of naturally eudesmane glycosides containing a -galactopyranoside moiety. The structure and relative configurations of these compounds were established by comprehensive analysis of MS and, in particular 1D/2D NMR spectroscopic data.

Apoptotic Potential and Antitumor Efficacy of Trilliumoside A: A New Steroidal Saponin Isolated from Rhizomes of .

Natural product-derived molecules exhibit potential as anticancer agents. Trilliumoside A, a new steroidal saponin, was obtained from rhizomes of , and its anticancer activity was investigated in the presented study. Trilliumoside A was investigated in a panel of cell lines, and it exhibited promising cytotoxic activity on the A549 cells (human lung cancer cells) with an IC of 1.

A novel carissic acid from fruits of induced apoptotic cell death in A-549 cells following the activation of caspases.

This study was designed to identify cytotoxic compounds from extract. The cytotoxic activity of extract and fractions were assessed against eight cancer cell lines. The chloroform fraction obtained from methanolic extract exhibited significant activity against MCF-7, HT-29, A-549 with IC values of 3.

HPLC-PDA Method for Quantification of Bioactive Compounds in Crude Extract and Fractions of Falc. and Cytotoxicity Studies against Cancer Cells.

Falc. (Synonym: Saussurea costus (Falc.) Lipsch.

anti-sickling potential of baicalin and naringenin isolated from and on human sickle red blood cells.

Sickle cell disease (SCD) is a rare inherited disorder in which red blood cells (RBCs) under oxidative stress have altered sickle shape resulting in clinical complications. In this study, a library of pure natural products were screened to see their effectiveness in preventing sickling induced in blood samples of SCA patients. The results indicated that baicalin () and naringenin (), reduced sickling by 46.

Reply to Letter to the Editor: A Fatal Case of Acute Disseminated Encephalomyelitis-A Diagnosis to Ponder in Pandemic.

Kumar A, Sabharwal P, Gupta P, Singh VK, Rao BK. Reply to Letter to the Editor: A Fatal Case of Acute Disseminated Encephalomyelitis-A Diagnosis to Ponder in Pandemic. Indian J Crit Care Med 2022;26(9):1062.

A Fatal Case of Acute Disseminated Encephalomyelitis: A Diagnosis to Ponder in Pandemic.

Unlabelled: A 40-year-old woman known hypertensive presented with progressive ascending paralysis. MRI T2W and FLAIR screening of the brain demonstrated swelling with altered signal in the visual cervical cord, medulla, and another juxtacortical lesion in the right temporal lobe with possibility of a demyelinating etiology. CSF testing did not identify a direct cerebral infection.

Secondary metabolites produced by Macrophomina phaseolina, a fungal root endophyte of Brugmansia aurea, using classical and epigenetic manipulation approach.

Endophytic fungi are rich sources of structurally complex chemical scaffolds with interesting biological activities. However, their metabolome is still unknown, making them appealing for novel compound discovery. To maximize the number of secondary metabolites produced from a single microbial source, we used the "OSMAC (one strain-many compounds) approach.

Biotransformation of eugenol by an endophytic fungus IIIMF4010 isolated from .

Natural value-added compounds produced from biological sources have attained immense significance in medicinal, food, flavourings, and agrochemical industries. Further, biotransformation is a powerful tool used to produce value-added compounds cost-effectively and selectively. In the present study, biotransformation of eugenol using an endophytic fungus IIIMF4010 isolated from the fresh leaves of the plant leads to the production of two known value-added compounds.

Comparative morpho-anatomical standardization and chemical profiling of root drugs for distinction of fourteen species of family Apocynaceae.

Background: The root drugs of the family Apocynaceae are medicinally important and used in Indian Systems of Medicine (ISM). There is often a problem of misidentification and adulteration of genuine samples with other samples in the market trade. Keeping in view the adulteration problem of raw drug material, comparative macroscopic and microscopic (qualitative and quantitative) characterisation and chemical analysis (TLC and LC-MS profiling) of a total of 14 economically important root drugs of family Apocynaceae were done for practical and rapid identification.

and Symbiosis: A Natural Mine of Bioactive Compounds.

Phylum Nematoda is of great economic importance. It has been a focused area for various research activities in distinct domains across the globe. Among nematodes, there is a group called entomopathogenic nematodes, which has two families that live in symbiotic association with bacteria of genus and , respectively.

-Derived Phytopharmaceutical Drug Has Potent Anti-dengue Activity.

Dengue is a serious public health concern worldwide, with ∼3 billion people at risk of contracting dengue virus (DENV) infections, with some suffering severe consequences of disease and leading to death. Currently, there is no broad use vaccine or drug available for the prevention or treatment of dengue, which leaves only anti-mosquito strategies to combat the dengue menace. The present study is an extension of our earlier study aimed at determining the and protective effects of a plant-derived phytopharmaceutical drug for the treatment of dengue.

Corrigendum: Coronarin K and L: Two Novel Labdane Diterpenes From : An Ayurvedic Crude Drug.

[This corrects the article DOI: 10.3389/fchem.2021.

Coronarin K and L: Two Novel Labdane Diterpenes From : An Ayurvedic Crude Drug.

The main objective of cancer treatment with chemotherapy is to kill the cancerous cells without affecting the healthy normal cells. In the present study, bioactivity-guided purification of the -chloroform soluble fraction from the methanol extract of resulted in the identification of two new labdane diterpenes: coronarin K () and coronarin L (), along with eight known compounds, coronarin A (), bisdemethoxycurcumin (), kaempferol 3--methyl ether (), kaempferol (), fenozan acid (), 3-(3-methoxy,4-hydroxyphenyl)-2-propenoic acid ferulic acid (), caffeic acid (), and gallic acid (). The structural identification of new compounds ( and ) were determined by detailed analysis of 1D (H and C) and 2D NMR (COSY, HSQC, and HMBC) spectroscopic data.

Sentiment Analysis of Lockdown in India During COVID-19: A Case Study on Twitter.

With the rapid increase in the use of the Internet, sentiment analysis has become one of the most popular fields of natural language processing (NLP). Using sentiment analysis, the implied emotion in the text can be mined effectively for different occasions. People are using social media to receive and communicate different types of information on a massive scale during COVID-19 outburst.

A prospective 3 year study of clinical spectrum and outcome of dengue fever in ICU from a tertiary care hospital in North India.

Background And Aims: The incidence of specific complications and adverse outcomes in dengue patients needing admission to intensive care units (ICU) may be quite variable in different regions of India presumably because of different strains of dengue virus or due to re infection.

Methods: Patients admitted with acute febrile illness (AFI) with either positive IgM antibody or NS1 antigen for dengue were enrolled. Data were collected for 3 years (2015-2017).

Effect of imperfect homodyne visibility on multi-spatial-mode two-mode squeezing measurements.

We study the effect of homodyne detector visibility on the measurement of quadrature squeezing for a spatially multi-mode source of two-mode squeezed light. Sources like optical parametric oscillators (OPO) typically produce squeezing in a single spatial mode because the nonlinear medium is within a mode-selective optical cavity. For such a source, imperfect interference visibility in the homodyne detector couples in additional vacuum noise, which can be accounted for by introducing an equivalent loss term.

Expanding the chemical diversity through microorganisms co-culture: Current status and outlook.

Natural products (NPs) are considered as a cornerstone for the generation of bioactive leads in drug discovery programs. However, one of the major limitations of NP drug discovery program is "rediscovery" of known compounds, thereby hindering the rate of drug discovery efficiency. Therefore, in recent years, to overcome these limitations, a great deal of attention has been drawn towards understanding the role of microorganisms' co-culture in inducing novel chemical entities.

: A Friend or Foe in ICU (A Case Report with Solution).

or , also known as baker's yeast or brewer's yeast, is normally a nonpathogenic microbe. It is commonly used as a probiotic to prevent antibiotic-associated diarrhea. We present a case of a 77-year-old woman with uncontrolled diabetes who developed with use of containing probiotic after 5 days of treatment.

Preclinical development of gastro-protective botanical candidate from Woodfordia fruticosa (Linn.) Kurz: Chemical standardization, efficacy, pharmacokinetics and safety pharmacology.

Ethnopharmacological Relevance: Woodfordia fruticosa is traditionally used in the Ayurvedic system of medicine for the treatment of diarrhoea, poisoning, menstrual disorders, ulcers and fertility. In the present study, we report a standardized extract preparation through modern scientific approach for anti-ulcer activity.

Materials And Methods: The hydro-alcoholic extract of flowers of W.