Recent advances in Ugi reaction and its post-transformation strategies for crafting diverse indole frameworks.

Indoles and their fused analogues are ubiquitous structural scaffolds present in a plethora of bioactive natural products and pharmaceutical compounds, showcasing their importance in drug design and delivery. Since the discovery of isocyanide-based multicomponent reactions (IMCRs), especially the Ugi reaction, there has been exponential growth in the development of new methodologies based on the post-modification of the Ugi reaction. This has led to the creation of diverse heterocyclic scaffolds, macromolecules, and natural products.