Epidermolysis bullosa in a mother-infant dyad.

Epidermolysis Bullosa is an inherited mechanobullous disorder which presents in the neonatal period as blistering skin lesions. In this case report, we describe an uncommon presentation of Epidermolysis Bullosa Simplex in a term infant, weighing 2640 g, born to a mother who was also diagnosed with Epidermolysis Bullosa Pruriginosa during the course of the evaluation of her newborn. The clinical situation presented us with a unique dilemma with regard to routine newborn care practices including handling, skin and diaper care.

Evaluation of skeletal and dentoalveolar dimensions in patients with maxillary unilateral impacted canine: a cone beam computed tomographic study.

Objective: To assess the skeletal and dentoalveolar dimensions of subjects with the unilateral maxillary-impacted canine and compare it with the non-impacted side using cone beam computed tomography (CBCT).

Methods: A split-mouth study that included 26 CBCTs (52 sides) with unilateral impacted canine was designed. The parameters analyzed were alveolar height; bucco palatal width at 2 mm, 6 mm, and 10 mm from alveolar crest; premolar width; lateral angulation of incisors; root length of lateral incisors; and crown-root angulation of lateral incisors.

Long-term follow-up of tobacco cessation intervention in a dental setting: A randomized trial.

Aims And Objectives: Tobacco dependence is widely prevalent and a harmful chronic disorder. Achieving long-term tobacco abstinence is an important public health goal. This study aims to assess the long-term effectiveness of moderate-intensity treatment for tobacco cessation in the dental clinic setting.

Defining the volume of rabies immunoglobulins/ rabies monoclonal antibodies requirement for wound infiltration of category III animal exposures - an exploratory study.

WHO recommends infiltration of rabies immunoglobulins/rabies monoclonal antibodies as anatomically possible, into or close to all category III animal bite wound(s)/exposures for post exposure prophylaxis. The volume required for wound infiltration depending upon the site/size/severity of wound is yet to be defined for guiding the treating physicians. This study aimed to determine the volume of rabies immunoglobulin/rabies monoclonal antibody required for wound infiltration depending upon the site, size, and severity.

Early detection of Parkinson's disease through patient questionnaire and predictive modelling.

Early detection of Parkinson's disease (PD) is important which can enable early initiation of therapeutic interventions and management strategies. However, methods for early detection still remain an unmet clinical need in PD. In this study, we use the Patient Questionnaire (PQ) portion from the widely used Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) to develop prediction models that can classify early PD from healthy normal using machine learning techniques that are becoming popular in biomedicine: logistic regression, random forests, boosted trees and support vector machine (SVM).

Laser Calorimetry Spectroscopy for ppm-level Dissolved Gas Detection and Analysis.

In this paper we report a newly developed technique - laser calorimetry spectroscopy (LCS), which is a combination of laser absorption spectroscopy and calorimetry - for the detection of gases dissolved in liquids. The technique involves determination of concentration of a dissolved gas by irradiating the liquid with light of a wavelength where the gas absorbs, and measuring the temperature change caused by the absorbance. Conventionally, detection of dissolved gases with sufficient sensitivity and specificity was done by first extracting the gases from the liquid and then analyzing the gases using techniques such as gas chromatography.

Hemifacial hypertrophy: Exploring new avenues of treatment modalities.

Congenital hemihyperplasia is a rare developmental disorder characterized by unilateral overgrowth of one or more body parts resulting in marked asymmetry. We are reporting here, a case of true hemifacial hypertrophy in a young female adult highlighting the clinical features and possible treatment options.

High-Accuracy Classification of Parkinson's Disease Through Shape Analysis and Surface Fitting in 123I-Ioflupane SPECT Imaging.

Early and accurate identification of Parkinsonian syndromes (PS) involving presynaptic degeneration from nondegenerative variants such as scans without evidence of dopaminergic deficit (SWEDD) and tremor disorders is important for effective patient management as the course, therapy, and prognosis differ substantially between the two groups. In this study, we use single photon emission computed tomography (SPECT) images from healthy normal, early PD, and SWEDD subjects, as obtained from the Parkinson's Progression Markers Initiative (PPMI) database, and process them to compute shape- and surface-fitting-based features. We use these features to develop and compare various classification models that can discriminate between scans showing dopaminergic deficit, as in PD, from scans without the deficit, as in healthy normal or SWEDD.

High-Accuracy Detection of Early Parkinson's Disease through Multimodal Features and Machine Learning.

Early (or preclinical) diagnosis of Parkinson's disease (PD) is crucial for its early management as by the time manifestation of clinical symptoms occur, more than 60% of the dopaminergic neurons have already been lost. It is now established that there exists a premotor stage, before the start of these classic motor symptoms, characterized by a constellation of clinical features, mostly non-motor in nature such as Rapid Eye Movement (REM) sleep Behaviour Disorder (RBD) and olfactory loss. In this paper, we use the non-motor features of RBD and olfactory loss, along with other significant biomarkers such as Cerebrospinal fluid (CSF) measurements and dopaminergic imaging markers from 183 healthy normal and 401 early PD subjects, as obtained from the Parkinson's Progression Markers Initiative (PPMI) database, to classify early PD subjects from normal using Naïve Bayes, Support Vector Machine (SVM), Boosted Trees and Random Forests classifiers.

Prevalence of oral mucosal lesions among chewing tobacco users: A cross-sectional study.

Context: The increasing use of chewing tobacco (CT) in the last 10-12 years has led to an increased incidence of potentially malignant oral disorders and frank oral malignancies.

Aim: To determine the frequency of oral mucosal lesions and to correlate the dose-response relationship among CT users of Bengaluru North province.

Settings And Design: This population-based cross-sectional study was conducted among a randomized cluster sample of adults in low-income group (slums), of Bengaluru North, Karnataka state, India.

Ocular Injuries Associated with Midface Fractures: A 5 Year Survey.

Aim: The aim of this study is retrospective analysis of ocular injuries after maxillofacial trauma reporting to the Department of Oral and Maxillofacial Surgery at V.S. Dental College and Kempegowda Institute of Medical Sciences and Hospital, Bangalore.

Hereditary sensory and autosomal peripheral neuropathy-type IV: case series and review of literature.

Hereditary sensory and autonomic neuropathy (HSAN) IV is a rare autosomal recessive disorder which is characterized by a decrease in the number of myelinated and non-myelinated nerve fibers of peripheral nerves which causes diminished or absent pain sensation leading to increase in self-mutilative habits. A retrospective study of eight cases ranging from age group of 4 to 17 years for oral and digital signs and symptoms is presented. All the patients showed congenital insensitivity to pain and anhidrosis.

Parkinson's disease detection using olfactory loss and REM sleep disorder features.

In Parkinson's disease, there exists a prodromal or a premotor phase characterized by symptoms like olfactory loss and sleep disorders, which may last for years or even decades before the onset of motor clinical symptoms. Diagnostic tools based on machine learning using these features can be very useful as they have the potential in early diagnosis of the disease. In the paper, we use olfactory loss feature from 40-item University of Pennsylvania Smell Identification Test (UPSIT) and Sleep behavior disorder feature from Rapid eye movement sleep Behavior Disorder Screening Questionnaire (RBDSQ), obtained from the Parkinson's Progression Marker's Initiative (PPMI) database, to develop automated diagnostic models using Support Vector Machine (SVM) and classification tree methods.

Dens invaginatus (dilated odontome) in mandibular canine.

Dens invaginatus is a developmental malformation of teeth related to shape of the teeth. Affected teeth show a deep infolding of enamel and dentin starting from the tip of the cusps and may extend deep into the root. It results from the invagination of the enamel organ into the dental papilla before calcification has occurred.

Evaluation of versatility and effectiveness of pedicled buccal fat pad used in the reconstruction of intra oral defects.

Introduction: The use of buccal fat pad as a grafting source in the closure of intraoral defects has gained popularity in the last quarter of this century. Because of the ease of access and rich blood supply, its use in oral defects is an attractive concept.

Methodology: The study comprised of 8 patients with oral submucous fibrosis, 1 patient with oroantral fistula, 1 patient with verrucous hyperplasia.

Growth rate studies of marine ornamental fish Pomacentrus caeruleus in artificial conditions.

Aquaculture industry depends on development and testing of protocols for rearing and breeding of new aquaculture species as these techniques vary with species. In the present study attempts have been made to study the effect of temperature and salinity on the rate of growth of the marine ornamental fish, Pomacentrus caeruleus under artificial conditions. Results reveal the length and weight of the fish to increase gradually at an average rate of 0.