Refined methodology for quantifying virulence using .

Larvae of (the greater wax moth) are being increasingly used as a model to study microbial pathogenesis. In this model, bacterial virulence is typically measured by determining the 50% lethal dose (LD) of a bacterial strain or mutant. The use of to study pathogenesis, however, is challenging because of the extreme sensitivity of larvae to this bacterium.

Unusual giant plunging sublingual epidermoid cyst: A case report and review of literature.

Key Clinical Message: When treating a painless or asymptomatic mass in the submental or floor of the mouth, sublingual epidermoid cyst should be considered. Despite its irregularity, preventing malignant transformation is essential for a successful outcome.

Abstract: Dermoid and epidermoid cysts are rarely found in the head and neck region.

Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.

The nonphysiological nutrient levels found in traditional culture media have been shown to affect numerous aspects of cancer cell physiology, including how cells respond to certain therapeutic agents. Here, we comprehensively evaluated how physiological nutrient levels affect therapeutic response by performing drug screening in human plasma-like medium. We observed dramatic nutrient-dependent changes in sensitivity to a variety of FDA-approved and clinically trialed compounds, including rigosertib, an experimental cancer therapeutic that recently failed in phase III clinical trials.

Characterization of prolycopene-accumulated Tan mutant of .

Significant progress has been made in understanding carotenoid biosynthesis in tomato (), and most pathway genes have been cloned and characterized. However, isolation and characterization of novel fruit ripening mutants is a continuous and essential process. This study describes the characterization of the Tan (Tangerine) mutant of .

Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.

The non-physiological nutrient levels found in traditional culture media have been shown to affect numerous aspects of cancer cell physiology, including how cells respond to certain therapeutic agents. Here, we comprehensively evaluated how physiological nutrient levels impact therapeutic response by performing drug screening in human plasma-like medium (HPLM). We observed dramatic nutrient-dependent changes in sensitivity to a variety of FDA-approved and clinically trialed compounds, including rigosertib, an experimental cancer therapeutic that has recently failed in phase 3 clinical trials.

Neuromyelitis optica spectrum disorder with AQP4-IgG presenting as area postrema syndrome and progressing to myelitis: A rare case report.

Key Clinical Message: Neuromyelitis optica spectrum disorders can less commonly present with area postrema syndrome progressing to myelitis. Management involves intravenous glucocorticoids, plasma exchange, and preventive immunotherapy.

Abstract: Neuromyelitis optica spectrum disorders can less commonly present with area postrema syndrome progressing to myelitis.

Distributed Activation Energy Modeling and Py-GC/MS Studies on Pyrolysis of Different Printed Circuit Boards for Resource Recovery.

Printed circuit boards (PCBs) constitute an important segment of electronic waste that can be effectively utilized to recover valuable metals and organics. The present work is focused on the kinetics and product distribution from pyrolysis of three different PCB samples, viz., television PCB (TV PCB), motherboard PCB (MB PCB), and hard disk PCB (HD PCB).

Optimal use of glycerol co-solvent to enhance product yield and its quality from hydrothermal liquefaction of refuse-derived fuel.

Refuse-derived fuels (RDF) are rich in resources that make them an attractive feedstock for the production of energy and biofuels. Hydrothermal liquefaction (HTL) is a promising thermochemical conversion technology to handle wet feedstocks and convert them to valuable bio-crude, bio-char and aqueous products. This study highlights the advantages of using glycerol as the co-solvent along with water in different proportions to produce bio-crude from RDF via HTL.

First case report of Mycobacterium canariasense native mitral valve endocarditis.

Mycobacterium canariasense is a relatively newly discovered, rapidly growing nontuberculous Mycobacterium first described in 17 patients with fever in the Canary Islands, Spain, in 2004. To date, there have been very few case reports in literature, and to our knowledge, infective endocarditis due to M. canariasense has not been reported.

Impact of dental operating microscope, selective dentin removal and cone beam computed tomography on detection of second mesiobuccal canal in maxillary molars: A clinical study.

Introduction: Maxillary molars may frequently require root canal therapy and can have complex anatomy. It is important to locate and treat the second mesiobuccal canal to significantly improve prognosis.

Aim Of The Study: The purpose of this study was to evaluate direct vision, dental operating microscope (DOM), selective dentin removal under DOM, and cone beam computed tomography (CBCT) in clinical detection of second mesiobuccal root canal (MB2) in maxillary molars.

Measurement of the Permanent Electric Dipole Moment of the Neutron.

We present the result of an experiment to measure the electric dipole moment (EDM) of the neutron at the Paul Scherrer Institute using Ramsey's method of separated oscillating magnetic fields with ultracold neutrons. Our measurement stands in the long history of EDM experiments probing physics violating time-reversal invariance. The salient features of this experiment were the use of a ^{199}Hg comagnetometer and an array of optically pumped cesium vapor magnetometers to cancel and correct for magnetic-field changes.

Comparison of anticancer activity of biocompatible ZnO nanoparticles prepared by solution combustion synthesis using aqueous leaf extracts of Abutilon indicum, Melia azedarach and Indigofera tinctoria as biofuels.

Recently, there has been an upsurge in the use of naturally available fuels for solution combustion synthesis (SCS) of nanoparticles. Although many reports suggest that these biofuels pose less harm to the environment, their strategic advantages and reliability for making NPs has not been discussed. In the present work, we try to address this issue using plant extracts as biofuels for the SCS of zinc oxide nanoparticles as a model system.

Everolimus plus octreotide long-acting repeatable in advanced neuroendocrine tumors in the routine tertiary cancer care setting: An Indian experience.

Background: Neuroendocrine tumors (NETs) are rare, heterogeneous, indolent tumors that are relatively insensitive to systemic chemotherapy. Therapeutic strategies for NETs broadly include somatostatin analogs, antiangiogenic therapy, and most recently, mammalian target of rapamycin inhibition. Combination therapy has shown promising antitumor activity and good tolerability in the randomized phase III trials.

Observation of Gravitationally Induced Vertical Striation of Polarized Ultracold Neutrons by Spin-Echo Spectroscopy.

We describe a spin-echo method for ultracold neutrons (UCNs) confined in a precession chamber and exposed to a |B0|=1  μT magnetic field. We have demonstrated that the analysis of UCN spin-echo resonance signals in combination with knowledge of the ambient magnetic field provides an excellent method by which to reconstruct the energy spectrum of a confined ensemble of neutrons. The method takes advantage of the relative dephasing of spins arising from a gravitationally induced striation of stored UCNs of different energies, and also permits an improved determination of the vertical magnetic-field gradient with an exceptional accuracy of 1.

Highly stable atomic vector magnetometer based on free spin precession.

We present a magnetometer based on optically pumped Cs atoms that measures the magnitude and direction of a 1 μT magnetic field. Multiple circularly polarized laser beams were used to probe the free spin precession of the Cs atoms. The design was optimized for long-time stability and achieves a scalar resolution better than 300 fT for integration times ranging from 80 ms to 1000 s.

An invitro evaluation of antibacterial properties of self etching dental adhesive systems.

Background And Objectives: The microbial flora of the oral cavity is extremely diverse. Residual bacteria in the oral cavity may remain at the tooth restoration interface and increase the risk of developing recurrent caries. The aim of this study is to evaluate the immediate and long term antibacterial effect of polymerised self etching adhesive systems.

Impact of anemia on in-hospital, one-month and one-year mortality in patients with acute coronary syndrome from the Middle East.

Aim: The aim of this study was to evaluate the impact of admission anemia on in-hospital, one-month, and one-year mortality in patients from the Middle East with acute coronary syndrome (ACS).

Methods: Data were analyzed from 7922 consecutive patients admitted to hospitals throughout six Middle-Eastern countries with the final diagnosis of ACS, as part of Gulf RACE II (Registry of Acute Coronary Events II). Anemia at admission was defined according to the World Health Organization definition (<13 g/dL in men and <12 g/dL in women).

Prevalence of early childhood caries in 8 - 48 month old preschool children of Bangalore city, South India.

Early Childhood Caries (ECC) is a devastating form of dental decay having a multi - factorial origin. This study was undertaken to determine the prevalence of ECC in Bangalore city, South India, and also to study its associated risk factors. Random sample of 1500 children, aged between 8 - 48 months, was selected from play homes and nursing homes of various parts of the city.

A large left atrial myxoma detected in emergency department using bedside transthoracic echocardiography.

We present a case of a 55-year-old woman with episodes of recurrent pulmonary edema that was diagnosed to have a large left atrial myxoma using bedside transthoracic echocardiography. This case illustrates the importance of a screening focused ultrasound examination of involved systems by emergency physicians in detecting causes for emergency clinical presentations.

Assessment of right ventricular diastolic function by tissue Doppler imaging in patients with acute right ventricular myocardial infarction.

Background: It is known that right ventricular systolic parameters as assessed by color tissue Doppler imaging (TDI) are abnormal in patients with inferior wall ST elevation myocardial infarction (IWMI) with right ventricular myocardial infarction (RVMI). This study was undertaken to determine right ventricular diastolic function as assessed by TDI in patients with acute RVMI.

Methods: Thirty-five patients with first IWMI were studied and compared with 20 age-matched healthy controls, and categorized into those with (14 patients) and without (21 patients) RVMI based on standard ECG criteria.

Prevalence and risk factors for albuminuria among type 2 diabetes mellitus patients: a Middle-East perspective.

The aim of the study was to determine the prevalence and risk factors for albuminuria among 447 type 2 diabetic patients in three Gulf countries. Overall prevalence of albuminuria was 36%, which is similar to that reported in other DEMAND studies and was strongly related to poor glycemic control.

Primary antiphospholipid syndrome with recurrent coronary thrombosis, acute pulmonary thromboembolism and intracerebral hematoma.

We present a young patient with myocardial infarction who had recurrent coronary thrombosis, in-stent thrombosis, and a major pulmonary arterial thromboembolism due to primary antiphospholipid syndrome. He also developed multiple intracerebral hematomas following anticoagulation therapy and thrombolysis. We describe this rare case of primary antiphospholipid syndrome presenting with varied arterial abnormalities along with hemorrhage and highlight the need for caution while treating them with anticoagulants and thrombolytics.

A rare presentation of primary antiphospholipid syndrome.

This case presents a young patient with myocardial infarction, in-situ thrombosis of left anterior descending coronary artery and right common-iliac artery due to primary antiphospholipid syndrome. This report discusses the relationship between antiphospholipid antibodies and coronary artery disease along with management of this rare condition.