Publications by authors named "Prashant Shambharkar"

With the massive expansion of videos on the internet, searching through millions of them has become quite challenging. Smartphones, recording devices, and file sharing are all examples of ways to capture massive amounts of real time video. In smart cities, there are many surveillance cameras, which has created a massive volume of video data whose indexing, retrieval, and administration is a difficult problem.

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Intracellular calcium signaling is critical for initiating and sustaining diverse cellular functions including transcription, synaptic signaling, muscle contraction, apoptosis and fertilization. Trans-membrane 203 (TMEM203) was identified here in cDNA overexpression screens for proteins capable of modulating intracellular calcium levels using activation of a calcium/calcineurin regulated transcription factor as an indicator. Overexpression of TMEM203 resulted in a reduction of Endoplasmic Reticulum (ER) calcium stores and elevation in basal cytoplasmic calcium levels.

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The IkappaB kinase (IKK) complex serves as the master regulator for the activation of NF-kappaB by various stimuli. It contains two catalytic subunits, IKKalpha and IKKbeta, and a regulatory subunit, IKKgamma/NEMO. The activation of IKK complex is dependent on the phosphorylation of IKKalpha/beta at its activation loop and the K63-linked ubiquitination of NEMO.

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Receptor-interacting protein (RIP) plays a critical role in tumor necrosis factor-alpha (TNF-alpha)-induced IkappaB kinase (IKK) activation and subsequent activation of transcription factor NF-kappaB. However, the molecular mechanism by which RIP mediates TNF-alpha-induced NF-kappaB activation is not completely defined. In this study, we have found that TAK1 is recruited to the TNF-alpha receptor complex in a RIP-dependent manner following the stimulation of TNF-alpha receptor 1 (TNF-R1).

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Article Synopsis
  • A study in New Delhi assessed 62,475 children under 5 from slums to identify severe rotavirus diarrhea over a year, finding that 23.5% of hospitalized diarrhea cases tested positive for rotavirus.
  • Most cases occurred in younger children, peaking between 9-11 months, with a year-round presence but higher rates in winter.
  • The dominant rotavirus strains were G1, G9, and G2, with G1 linked to more severe diarrhea cases, indicating a significant public health concern for young children in the area.
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Molecular cloning and characterization of a novel cry gene, cry32Aa, of Bacillus thuringiensis subsp. yunnanensis was carried out. The Cry32Aa protein was predicted to have a molecular mass of 139.

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