Clinico-immunological evaluation of use of omega-3 fatty acids as nutraceutical approach in management of patients with chronic periodontitis: A randomized clinical trial.

Background: Subgingival bacterial colonization and biofilm formation are known to be the main etiology of periodontal disease progression. This biofilm elicits host response and the interaction between host defence mechanisms with plaque microorganisms and their products results in periodontal disease. Host modulatory therapy (HMT) is a form of treatment of periodontitis that focuses on treatment of the host in the host-bacteria interaction.

Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocyclization.

The G-quartet-like supramolecular assembly present in guanosine hydrogel templates macrocyclization between bis-azide and bis-alkyne fragments. The resulting macrocycle enhances viscoelastic properties, and strengthens the hydrogel network. This approach holds potential for the synthesis of drugs and their simultaneous delivery in a stimuli-responsive manner.

A comparative evaluation of management of hyperpigmented gingiva using surgical stripping technique and diode laser: A clinical study.

Background: To compare the treatment outcome of laser and its effectiveness in the management of gingival hyperpigmentation over scalpel surgical method.

Methods: The patients were selected and were divided into two groups by the split-mouth design. : Right half upper and lower central incisors to premolars were treated using the laser technique.

Comparative Analysis of Cluster of Differentiation 57 and Proliferating Cell Nuclear Antigen Expression in Different Grades of Oral Squamous Cell Carcinoma: An Immunohistochemical Study.

Background:  The immune defense against tumor cells is mainly mediated by the natural killer (NK) cells. Cluster of differentiation 57 (CD57) is a 110-kd glycoprotein, typically expressed by the NK cells, attacks the cancer cells and inhibits tumor development. Proliferating cell nuclear antigen (PCNA) is a 36-kd auxiliary protein for DNA polymerase delta that correlates with cell proliferation and DNA synthesis.

Expanding the Toolbox of Target Directed Bio-Orthogonal Synthesis: In Situ Direct Macrocyclization by DNA Templates.

Herein, we demonstrate for the first time that noncanonical DNA can direct macrocyclization-like challenging reactions to synthesize gene modulators. The planar G-quartets present in DNA G-quadruplexes (G4s) provide a size complementary reaction platform for the bio-orthogonal macrocyclization of bifunctional azide and alkyne fragments over oligo- and polymerization. G4s immobilized on gold-coated magnetic nanoparticles have been used as target templates to enable easy identification of a selective peptidomimetic macrocycle.

Plasma cell gingivitis: A perplexing and rare clinical entity.

Plasma cell gingivitis (PCG) is a diagnostic dilemma for clinicians. It is also referred to as atypical gingivostomatitis, idiopathic gingivostomatitis, allergic gingivostomatitis, and plasma cell gingivostomatitis which are characterized by bright fiery red gingiva with spontaneous bleeding on slight provocation. It is often confused with inflammatory gingival enlargement, erythematosus lichen planus, and other lesions.

Deep Learning for Interictal Epileptiform Spike Detection from scalp EEG frequency sub bands.

Epilepsy diagnosis through visual examination of interictal epileptiform discharges (IEDs) in scalp electroencephalogram (EEG) signals is a challenging problem. Deep learning methods can be an automated way to perform this task. In this work, we present a new approach based on convolutional neural network (CNN) to detect IEDs from EEGs automatically.

A Competitive Pull-Down Assay Using G-quadruplex DNA Linked Magnetic Nanoparticles To Determine Specificity of G-quadruplex Ligands.

Herein, we develop a competitive screening method in which G-quadruplex DNA linked magnetic nanoparticles pull down selective ligands for a particular quadruplex topology from a series of small molecules. The screening strategy is first optimized with known G-quadruplex ligands and then used with a new series of G-quadruplex interactive bis-triazolyl ligands that are synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition. The assay enables the identification of c-MYC and BCL2 G-quadruplex selective bis-triazole ligands that specifically target promoter G-quadruplexes in cancer cells.

Kimura's disease: A case presentation of postauricular swelling.

Kimura's disease (KD) is a rare chronic inflammatory disease of subcutaneous tissues and occurs predominantly in head and neck region. It is seen primarily in young Asian males. Typical clinical presentations are painless subcutaneous masses, regional lymph node enlargement, blood and tissue hypereosinophilia, and increased serum IgE levels.

Central mucoepidermoid carcinoma.

Central mucoepidermoid carcinomas (MECs) are extremely rare tumors, comprising 2-3% of all MECs reported in the literature. We report a rare case of clear cell variant of central MEC with calcifications occurring in the left posterior mandible in a 37-year-old male patient.

Management of large periapical cystic lesion by aspiration and nonsurgical endodontic therapy using calcium hydroxide paste.

Aim: To report a case of conservative nonsurgical management of periapical lesions.

Background: Small periapical lesions of endodontic origin usually heal by conventional endodontic therapy alone. Larger periapical lesions presumed to be cystic may require additional treatment protocols to aid in regression.

Histopathological and radiographic evaluation of rat molar teeth after traumatic injury-a pilot study.

Objective: Radiographic and histopathological evaluation of mechanical trauma on the development of maxillary molars in rat.

Materials And Methods: Experimental study with 7-day-old five new born Wistar rats. Trauma induced on 7(th) postnatal day with #55 K file.

Evaluation of Aerosol and Water Contamination and Control of Cross Infection in Dental Clinics.

Background: The oral cavity is an unique environment which provides an ideal medium for bacterial growth. As a result of repeated exposure to the microorganisms present in blood and saliva, the dental health professionals and the patients are at a higher risk for developing many infectious diseases. A pilot study was carried out in the Dept of Dental Surgery, Armed Forces Medical College to assess the risk of cross infection in dental clinics.

Management of localized gingival recession by two-stage surgical procedure - Double pedicle flap with CTG and coronally advanced flap: A novel technique.

Cosmetic treatments have become an integral part of periodontal treatment. One of the commonly used esthetic periodontal procedures is coverage of denuded root surface. While considering the elimination of these defects two criteria should be considered, the esthetic aspects and the functional aspects.

Effect of mechanical trauma on the tooth germ of rat molar--a scanning electron microscope study.

Objective: Clinical and histopathological evaluation of mechanical trauma on the development of maxillary first molar with Scanning Electron Microscope.

Design: Experimental study with four newborn Wistar rats. Trauma induced on 1st, 3rd, 7th and 10th postnatal days with dental K file.