Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure.

Recent literature reports highlight the importance of the renal outer medullary potassium (ROMK) channel in renal sodium and potassium homeostasis and emphasize the potential impact that ROMK inhibitors could have as a novel mechanism diuretic in heart failure patients. A series of piperazine-based ROMK inhibitors were designed and optimized to achieve excellent ROMK potency, hERG selectivity, and ADME properties, which led to the identification of compound (BMS-986308). BMS-986308 demonstrated efficacy in the volume-loaded rat diuresis model as well as promising in vitro and in vivo profiles and was therefore advanced to clinical development.

A Pilot, Prospective, Randomized-Controlled Study to Evaluate the Efficacy and Safety of Arsha Hita™ in the Treatment of Anal Fissures.

Introduction Anal fissures are tears in the anal canal that cause pain, bleeding, and spasms. They can be treated with non-operative options such as sitz baths, local anesthetics, topical nitrates, oral fiber, and calcium channel blockers, but some patients require surgery. Topical nitrates have side effects such as severe headaches, while topical calcium channel blockers can cause itching.

Locating block caused by stuck PIGs in multi product pipeline using combination of radioisotope techniques.

Blockages in pipelines inhibit the normal use of the pipeline due to constricted flow of fluid through the pipeline. Locating blockages in pipelines is a challenge and there is an increasing demand for sensitive inspection methods to locate blockages in pipelines, caused either due to presence of foreign undesired material during commissioning or maintenance of the pipeline or due to accumulation of product remanent during the prolonged use of the pipelines. A block was caused in a multiproduct pipeline due to a stuck pig (pipe inspection gauge).

Apprehensions and Optimism among Dental Professionals during the COVID-19 Pandemic-A Nationwide Cross-Sectional Evaluation.

Globally, the pandemic of the coronavirus disease, which started in Wuhan, China, has become a major issue for public health. The COVID-19 epidemic notably causes health professionals to experience significantly more emotional stress than the general populace. The present study proposes to investigate the fear aspect in dentists in the initiation of clinical practice during these times.

Chondroblastic Variant of Osteosarcoma Mandible-an Intent to Cure.

Osteosarcoma is one of the rarer malignancies that affects the facial skeletal structures. There are only a few retrospective studies discussing the management and outcomes of this malignancy due to the rarity of the disease. Unlike osteosarcoma of long bones, this malignancy has more incidence in patients in the older age group leading to difficulty in the management of this condition but with better outcomes due to the contrasting behavior of this malignancy.

Improvements in Depression Outcomes Following a Digital Cognitive Behavioral Therapy Intervention in a Polychronic Population: Retrospective Study.

Background: Digital mental health interventions have shown promise in reducing barriers to effective care for depression. Depression and related mental disorders are known to be highly comorbid with common chronic physical conditions, such as obesity and type 2 diabetes. While some research has explored the interaction dynamics of treating populations living with both mental and physical disorders, very little is known about such dynamics in digital care.

Knowledge, attitude and practice of dental students and practitioners during the early days of COVID-19 pandemic in India: A cross-sectional study.

Aim: The novel coronavirus disease-2019 (COVID-19) is a major health problem and has affected innumerable people around the world. The current online-based study was conducted to assess the knowledge, attitude and practice (KAP) of dental students and professionals during the early days of lockdown in India from 2 April to 1 May 2020.

Methodology: An online-based cross-sectional study was undertaken through WhatsApp messenger and e-mail groups among dental students and professionals.

Nonsyndromic delayed eruption of multiple teeth: A rare case report.

Dental eruption is a very finely regulated process. A delay in tooth eruption may be due to a disturbance caused by local, systemic, or genetic abnormalities. Delayed eruption of multiple teeth in the absence of any etiology is very rare.

SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ.

Pathological lipid accumulation is often associated with enhanced uptake of free fatty acids via specific transporters in cardiomyocytes. Here, we identify SIRT6 as a critical transcriptional regulator of fatty acid transporters in cardiomyocytes. We find that SIRT6 deficiency enhances the expression of fatty acid transporters, leading to enhanced fatty acid uptake and lipid accumulation.

The Indian Network of Drug-Induced Liver Injury: Etiology, Clinical Features, Outcome and Prognostic Markers in 1288 Patients.

Background: Etiology of and outcomes following idiosyncratic drug-induced liver injury (DILI) vary geographically. We conducted a prospective study of DILI in India, from 2013 to 2018 and summarize the causes, clinical features, outcomes and predictors of mortality.

Methods: We enrolled patients with DILI using international DILI expert working group criteria and Roussel Uclaf causality assessment method.

3D printing guided closure of submitral aneurysm-an interesting case.

Submitral aneurysm is a congenital outpouching of the left ventricular wall invariably occurring adjacent to the posterior leaflet of the mitral valve. It usually presents with heart failure symptoms. We report a case of a 59-year-old gentleman with a posterolateral submitral aneurysm who underwent aneurysm patch repair and mitral valve repair.

Aberrant Aortopulmonary Venous Fistula: An Intraoperative Surprise.

An isolated systemic artery to pulmonary vein arteriovenous fistula is a rare clinical entity. We report a 20-year-old woman diagnosed with myxomatous mitral valve prolapse with severe mitral regurgitation and planned for mitral valve repair. An aberrant aortopulmonary venous fistula was suspected intraoperatively due to flooding of the left atrium with blood from the left inferior pulmonary vein on cardiopulmonary bypass.

An integrated approach for the management of diabetic foot ulcer: a case report.

Diabetic foot ulcers (DFUs) are the results of the combined effects of diabetes-related vascular disease and neuropathy. DFUs are responsible for more hospitalizations than any other complication of diabetes. It can impair patients' quality of life and affect social participation and livelihood.

The star-crossed curse of childhood: A case of infantile hemangioma.

Vascular lesions are indeed very widespread, with vascular tumors numbering the most common tumors in childhood. Researchers and authors frequently use the idiom "hemangioma" to portray or describe vascular malformations and a potpourri of vascular anomalies. Infantile hemangioma, a type of hemangioma, is one of the most common benign vascular tumors in infancy and childhood.

Use of EHRs data for clinical research: Historical progress and current applications.

The benefits of reusing EHR data for clinical research studies are numerous. They portend the opportunity to bring new therapies to patients sooner, potentially at a lower cost, and to accelerate learning health cycles-through faster data acquisition in clinical research studies. Metrics have proven that time can be saved, workflow and processes streamlined, and data quality increased significantly.

Corrigendum to "Fibrous Dysplasia versus Juvenile Ossifying Fibroma: A Dilemma".

[This corrects the article DOI: 10.1155/2016/6439026.].

Axillary dissection for breast cancer using electrocautery versus ultrasonic dissectors: A prospective randomized study.

Background: The major morbidities of modified radical mastectomy both short- and long-term are sequelae of axillary dissection. Flap complications, prolonged seroma, need for axillary drainage, wound infection, lymphedema, shoulder stiffness, and paresthesia are major causes for morbidity after axillary dissection. Different techniques have been implemented to tackle these problems.

Fibrous Dysplasia versus Juvenile Ossifying Fibroma: A Dilemma.

Fibrous dysplasia (FD) is a condition characterized by excessive proliferation of bone forming mesenchymal cells which can affect one bone (monostotic type) or multiple bones (polyostotic type). It is predominantly noticed in adolescents and young adults. Fibrous dysplasia affecting the jaws is an uncommon condition.

PTMC in post-MV repair status.

MV repair in the rheumatic population is feasible with acceptable long-term results. Incidence of mitral stenosis (MS) following mitral valve (MV) repair for severe rheumatic mitral regurgitation (MR) and usefulness of percutaneous transluminal mitral valvuloplasty (PTMC) in these patients is not described in literature. We report a case of successful PTMC in severe MS following MV repair for severe rheumatic MR.

Exploratory studies on the therapeutic effects of Kumarabharana Rasa in the management of chronic tonsillitis among children at a tertiary care hospital of Karnataka.

The effect of an Ayurvedic poly-herbo-mineral formulation Kumarabharana Rasa (KR) in the management of chronic tonsillitis (Tundikeri) in children has been assessed in this study. This clinical study was a double-arm study with a pre- and post-test design at the outpatient level in a tertiary Ayurveda hospital attached to a teaching institute located in district headquarters in Southern India. Patients (n = 40) with chronic tonsillitis satisfying diagnostic criteria and aged between 5 and 10 years were selected from the outpatient Department of Kaumarbhritya, SDM College of Ayurveda and Hospital, Hassan.