Publications by authors named "Prasad Walke"
Nanoparticles are the focus of an increased interest in drug delivery systems for cancer therapy. Lipid-coated nanoparticles are inspired in structure and size by low-density lipoproteins (LDLs) because cancer cells have an increased need for cholesterol to proliferate, and this has been exploited as a mechanism for delivering anticancer drugs to cancer cells. Moreover, depending on drug chemistry, encapsulating the drug can be advantageous to avoid degradation of the drug during circulation in vivo.
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- The story begins in Basel, 2013, where Pieter introduces a solvent-exchange method for creating limit-sized nanoparticles aimed at delivering drugs to cancer cells using Low Density Lipoprotein (LDL) as a vehicle.
- The research emphasizes the bottom-up design process, detailing the stages of nucleation and growth of nanoparticles, demonstrating that classic nucleation theory can accurately predict nanoparticle sizes using the right parameters.
- Calculations show that smaller nanoparticles (50 nm) dissolve much faster than larger ones (500 nm) in the bloodstream, making them more effective for drug delivery; the study experiments with various nanoparticles, emphasizing the importance of an impermeable lipid coating.