Publications by authors named "Prasad Malladi"
Article Synopsis
- MSMCs are typically asymptomatic cysts but can lead to symptoms like urinary issues and pain in some patients, prompting this study.
- The research involved a thorough assessment of patients with symptomatic MSMCs, utilizing questionnaires and neurophysiology tests to understand the impact on nerve function.
- Findings revealed that symptomatic MSMCs frequently cause nerve damage, with a higher rate of injury compared to Tarlov cysts.
Article Synopsis
- Nonneurogenic chronic urinary retention is rare in young women, with Fowler syndrome being a primary cause, and while treatments like sacral neuromodulation are ideal, they aren't commonly accessible.
- A retrospective study reviewed 33 women treated with botulinum toxin A (BoTX-A) injections to address urinary retention due to Fowler syndrome over an 11-year period, finding that 64% of recipients responded positively after the treatment.
- The study concluded that periurethral botulinum toxin injections are a safe and effective long-term solution for managing this condition, offering a viable option when other treatments are unavailable.
Article Synopsis
- There may be a connection between Tarlov cysts (TCs) and neurological symptoms like pain and urogenital issues, prompting a study to examine this relationship.
- Researchers analyzed data from patients with sacral TCs using tests that measure pelvic nerve function and correlated these findings with clinical symptoms and MRI results.
- Of the 65 women studied, many reported symptoms such as pain and urinary issues, and over half had abnormal nerve function; however, there was no link between MRI results and these neurophysiological findings.
Article Synopsis
- The study evaluated the ongoing bladder, bowel, and sexual dysfunction in patients who experienced transverse myelitis due to MOG-Ab disease, even after they regained mobility.
- Researchers assessed twelve patients using clinical evaluations and specialized tests to explore these dysfunctions over a follow-up period of about 50 months.
- The findings revealed significant urinary issues, particularly in patients with conus lesions, and indicated that persistent urogenital problems may stem from higher-level spinal injuries rather than the conus itself.
Background: Acute demyelinating optic neuritis, a common feature of multiple sclerosis, can damage vision through neurodegeneration in the optic nerve and in its fibres in the retina. Inhibition of voltage-gated sodium channels is neuroprotective in preclinical models. In this study we aimed to establish whether sodium-channel inhibition with phenytoin is neuroprotective in patient with acute optic neuritis.
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