Publications by authors named "Prasad Krishnamurthy"

A composite material comprising expanded polystyrene (EPS), granulated tyre rubber (GTR), and a compatibilizer is demonstrated as a possible replacement for fine and coarse agglomerates in mortar and concrete systems, respectively. Two different polymer blending processes (solvent/low shear blending and melt/high shear blending) are used, and the resulting composite material utilized as aggregate to replace sand and cement for mortar and concrete block development. Critical properties such as workability, compressive and flexural strengths, water absorption, bulk density, and porosity are measured before and after aggregate replacement.

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Aims: There is minimal research on the duration of biofield experiences. This preliminary study used the experiential learning practice of Master Choa Kok Sui's hands sensitisation to determine the duration to experience biofield sensations in between hands and to find the relationship between learning style preferences and biofield sensations.

Methods: This randomized placebo controlled, single blinded trial included 88 male and female pre-service teachers, aged 22.

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Several environmental and techno-economic assessments highlighted the advantage of placing polystyrene-based materials in a circular loop, from production to waste generation to product refabrication, either following the mechanical or thermochemical routes. This review provides an assortment of promising approaches to solving the dilemma of polystyrene waste. With a focus on upcycling technologies available in the last five years, the review first gives an overview of polystyrene, its chemistry, types, forms, and varied applications.

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This study investigated the recovery of phytochemical antioxidants in fruit using different extraction solvents. The effects of solvent of varying polarities with sequential extraction method on the recovery of phenolics, flavonoids, carotenoids and anthocyanins from different parts of the fruit (seed, pulp and peel) were determined. Their antioxidant activities were further determined using DPPH radical, ferric reducing antioxidant power (FRAP), hydroxyl radical scavenging, superoxide anion radical scavenging and phosphomolybdenum method.

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Dacryodes rostrata (kembayau) is an important food and oil resource for local communities in Borneo, but it is not commonly known to wider community. The objective of this work is to valorize kembayau fruit by evaluating the characteristics of the oil from the fruit. In this study, the physicochemical characteristics and the lipophilic essential nutrient; the fatty acid composition, vitamin E and beta-carotene content of oils obtained from the peel, pulp and seeds of kembayau fruits were studied.

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Background And Purpose: Activators of K 11.1 (hERG) channels have potential utility in the treatment of acquired and congenital long QT (LQT) syndrome. Here, we describe a new hERG channel activator, 5-(((1H-indazol-5-yl)oxy)methyl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-2-amine (ITP-2), with a chemical structure distinct from previously reported compounds.

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The serine/threonine kinase IL-1R-associated kinase (IRAK)4 is a critical regulator of innate immunity. We have identified BMS-986126, a potent, highly selective inhibitor of IRAK4 kinase activity that demonstrates equipotent activity against multiple MyD88-dependent responses both in vitro and in vivo. BMS-986126 failed to inhibit assays downstream of MyD88-independent receptors, including the TNF receptor and TLR3.

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Kynurenine aminotransferases convert kynurenine to kynurenic acid and play an important role in the tryptophan degradation pathway. Kynurenic acid levels in brain have been hypothesized to be linked to a number of central nervous system (CNS) disorders. Kynurenine aminotransferase II (KATII) has proven to be a key modulator of kynurenic acid levels in brain and, thus, is an attractive target to treat CNS diseases.

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Organic cation transporter (OCT) 2, multidrug and toxin extrusion protein (MATE) 1, and MATE2K mediate the renal secretion of various cationic drugs and can serve as the loci of drug-drug interactions (DDI). To support the evaluation of cynomolgus monkey as a surrogate model for studying human organic cation transporters, monkey genes were cloned and shown to have a high degree of amino acid sequence identity versus their human counterparts (93.7, 94.

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Nanostructured titanium dioxide has been synthesized using both conventional and ultrasound assisted sol-gel technique with an objective of understanding the role of cavitational effects in the synthesis process. The experiments were conducted at a constant calcination temperature of 750 °C and the calcination time was varied from 30 min to 3 h to study the effect of calcination time on the properties of the synthesized TiO₂. The TiO₂ specimens were characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM).

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Cynomolgus monkeys are a commonly used species in preclinical drug discovery, and have high genetic similarity to humans, especially for the drug-metabolizing cytochrome P450s. However, species differences are frequently observed in the metabolism of drugs between cynomolgus monkeys and humans, and delineating these differences requires expressed CYPs. Toward this end, cynomolgus monkey CYP3A4 (c3A4) was cloned and expressed in a novel human embryonic kidney 293-6E cell suspension system.

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Intestinal alkaline phosphatases (IAPs) are involved in the cleavage of phosphate prodrugs to liberate the drug for absorption in the intestine. To facilitate in vitro characterization of phosphate prodrugs, we have cloned, expressed, purified and characterized IAPs from rat and cynomolgus monkey (rIAP and cIAP respectively) which are important pre-clinical species for drug metabolism studies. The recombinant rat and monkey enzymes expressed in Sf9 insect cells (IAP-Ic) were found to be glycosylated and active.

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Oesophageal intubation can lead to life threatening complications if left undetected. Several devices and techniques are available to confirm tracheal intubation and for early detection of oesophageal intubation. This study was carried out to evaluate the utility of the Umesh's intubation detector device for rapid and reliable differentiation of tracheal from oesophageal intubation by novice users.

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Organic anion-transporting polypeptides (OATP) 1B1, 1B3, and 2B1 can serve as the loci of drug-drug interactions (DDIs). In the present work, the cynomolgus monkey was evaluated as a potential model for studying OATP-mediated DDIs. Three cynomolgus monkey OATPs (cOATPs), with a high degree of amino acid sequence identity (91.

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Background: Interactive media are effective tools in teaching and allow for self-directed study, which develops skills for life-long learning among health professionals. With this type of study, the learner can review material at his/her own pace and target areas that require emphasis. Pediatric residents require an accurate understanding of developmental milestones in children of various ages and their normal variations.

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Nanostructured zirconium dioxide was synthesized from zirconyl nitrate using both conventional and ultrasound assisted precipitation in alkaline medium. The synthesized samples were calcinated at temperatures ranging from 400°C to 900°C in steps of 100°C. The ZrO(2) specimens were characterized using X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM).

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Titanium dioxide was successfully synthesized by utilizing sol-gel technique modified by incorporation of ultrasound as a reaction aid. The effect of amplitude of irradiation (power input varied from 19.9 to 80.

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An effort was made to synthesize nanostructured TiO(2) via sol-gel technique to obtain a 100% rutile polymorph of nanostructured TiO(2). The sol-gel synthesis technique was suitably modified by incorporating ultrasound to study the effect of cavitation on the phase transformation, crystallite size, crystallinity and morphological (scanning electron microscopy) properties of the obtained nano-TiO(2). It was observed that using ultrasound, yield of the nano-TiO(2) was improved from 86.

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