Successful topical rapamycin treatment for facial angiofibromata in two children.

Topical sirolimus, or rapamycin, is known to inhibit tumorigenesis in tuberous sclerosis. We report two cases of successful treatment of children with facial angiofibromata and summarize the encouraging evidence of the effectiveness of this therapy in the literature.

Evaluation of follicular T-helper cells in primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoma and dermatitis.

Background: CD4+ small/medium-sized pleomorphic T-cell lymphoma (SMPTCL) is a controversial primary cutaneous lymphoma, in which the candidate neoplastic cells express a follicular T-helper phenotype. We describe 16 cases of SMPTCL and compare expression of PD-1, CXCL-13 and ICOS in these tumors with 40 dermatitis cases.

Methods: Histopathologic examination and immunocytochemistry were performed for 16 tumors and 40 assorted dermatitis cases.

Atypical pattern of (meth)acrylate allergic contact dermatitis in dental professionals.

(Meth)acrylates in dental bonding agents are a common source of allergic contact dermatitis in dental professionals. The distribution of the contact dermatitis is commonly on finger tips, but is determined by individual habits as demonstrated by the two case reports in this article. Despite the site of contact dermatitis, the bonding agents are often not suspected as a source of contact allergy due to misconception regarding the protective effect of natural rubber latex gloves.

Review of the 90th annual meeting of the british association of dermatologists, 6-8 july 2010, manchester, UK.

This is a synopsis of the main research and clinical findings presented at the British Association of Dermatologists meeting held during 6-8 July 2010 in Manchester, U.K. The conference highlighted the biological, epidemiological and therapeutic advances that have been made recently in the field of dermatology.