Molecular Influence of the ATM Protein in the Treatment of Human Cells with Different Radioprotective Drugs: Comparisons between Antioxidative and Pro-Episkevic Strategies.

The radiation protection strategy with chemical agents has long been based on an antioxidative approach consisting in reducing the number of radical oxygen and nitrogen species responsible for the formation of the radiation-induced (RI) DNA damage, notably the DNA double-strand breaks (DSB), whose subset participates in the RI lethal effect as unrepairable damage. Conversely, a DSB repair-stimulating strategy that may be called the "pro-episkevic" approach (from the ancient Greek , meaning repair) can be proposed. The pro-episkevic approach directly derives from a mechanistic model based on the RI nucleoshuttling of the ATM protein (RIANS) and contributes to increase the number of DSB managed by NHEJ, the most predominant DSB repair and signaling pathway in mammalians.

Physiological and functional responses to low-moderate versus high-intensity progressive resistance training in frail elders.

Background: The purpose of this efficacy study was to measure the dose-response effect of a free weight-based resistance training program by comparing the effects of two training intensities (low-moderate and high) of the knee extensor (KE) muscles on muscle function, functional limitations, and self-reported disability.

Methods: The authors conducted a single-blinded, randomized, placebo-controlled trial. Twenty-two institutionalized elders (mean age, 81.

[Long-term treatment of Alzheimer's disease: followup of a cohort of 255 patients treated with lacrine for four years].

We describe the follow-up of a cohort of 255 Alzheimer's disease (AD) patients (81 males, 174 females) treated by tacrine during 4 years. We performed the survey of hepatic, cholinergic and general tolérance. Drug efficacy was measured by MMS examination on weeks 0, 18, 30, 52, 104, 156 and 208.

[Exercise test in patients over 70 years of age].

One hundred and sixty-four out of 171 prescribed tests were carried out (96 p. 100) in 48 women aged 70 to 85 years (mean 74,3 years), and 116 men aged 70 to 84 years (mean 73,4 years). The indications were: coronary artery disease (113 cases), cardiac arrhythmias (44 cases), cardiac failure (12 cases), hypertension (9 cases) and assessment of apparently normal subjects (7 cases).

[Hypochromic anemia and small bowel diverticula].

The authors appreciate the possible responsibility of small intestine diverticulosis in three patients with iron deficiency anemia. In the first case, anemia was associated with colo-duodenal fistula. In the second and third cases, because of the negativity of gastric and large bowel investigations, a barium opacification was done, which showed diverticulosis.

[The effect of various diseases on the zinc plasma level].

Zinc, an important enzymatic cofactor, takes part in numerous metabolic pathways. In man, zinc deficiencies may be due either to deficient absorption or to excessive use. In this study in 285 patients hospitalized in a department of internal medicine for acute or chronic conditions, serum zinc assays have shown the following results: serum zinc concentrations are significantly decreased in acute critical conditions (cardiovascular ischemic disorders, heart failure, infections); in chronic conditions, serum zinc is decreased in some instances (renal failure, cancer, alcoholism, diarrhea), while it remains normal in others (compensated heart failure, non-insulin dependent diabetes, arterial hypertension, obesity).

[Perforations of the colon and rectum during administration of barium enema. Six cases report (author's transl)].

Perforations of the colon and rectum during administration of barium enema. Six cases report. The authors have stated six cases of accidental perforation occurring during barium enema examination.

[Angio-immunoblastic lymphadenopathy occurring two years after a hypersensitive vasculitis (author's transl)].

The association of a drug related hypersensitive vasculitis followed two years later by angio-immunoblastic lymphadenopathy is reported. The hypothesis of a similar pathogenesis of these two conditions is discussed.

[Clinical value of the determination of serum digoxin levels (author's transl)].

The authors refer to the technique of the serum digoxin enzyme immunoassay, and they report the results of 297 dosages concerning 111 hospitalized patients. The normal plasmatic rates are of 1,4 +/- 0,6 microgram/l in patients who present no sign of digitalic overdosage. The rates are of 5,2 +/- 1,6 microgram/l in cases of intoxication.

[Piribedil, dopaminergic agonist and the cerebral neurovascular syndrom of the aging man (author's transl)].

In the aging brain, there is an alteration of neurotransmettor systems, essentially catecholaminergics (dopamine, noradrenaline). The experimental works which show the agonist effect of piribedil on cerebral dopaminergic systems are presented. The results of the action of piribedil in the cerebral neuro-vascular syndrom are analysed.

[Pulmonary mycobacteriosis due to Mycobacterium chelonei: a report on a new case (authors' transl)].

Mycobacterium chelonei is a saprophytic germ usually devoid of pathogenic activity. Over a period of about the last ten years, however, several cases have been reported, including twelve cases of bronchopulmonary affections, in which it has been the infecting organism. The radiographic appearance is in every respect similar to that observed in pulmonary tuberculosis.

[A case of idiopathic disseminated pulmonary ossification (author's transl)].

A patient aged 92 years was discovered to have disseminated pulmonary ossification of the interstitial tissues without any valvular cardiopathy. The authors underline the rarety of such ectopic ossifications and review their radiological, anatomical, and etiological characteristics as reported in the published literature.

[Radioclinical aspects of tibio-tibial diaphyseal toxo-pachyosteosis. Weismann-Netter and Stuhl disease. Two new cases (author's transl)].

The authors report two cases of individuals sufferring from bow-leggedness, which they attribute to tibio-fibular thoxo-pachyosteosis. On the basis of these new cases, they review the radioclinical characteristics of the diagnosis of Weismann-Netter and Stuhl tibio-fibular toxo-pachy-osteosis. This dysmorphic syndrome is usually familial, very likely of genetic origin, and characterised by the small stature of those affected with curving of the tibia and fibula with an anterior convexity and thickening of the posterior cortex of the bony diaphysis.