Probing the distinct chemosensitivity of Plasmodium vivax liver stage parasites and demonstration of 8-aminoquinoline radical cure activity in vitro.

Improved control of Plasmodium vivax malaria can be achieved with the discovery of new antimalarials with radical cure efficacy, including prevention of relapse caused by hypnozoites residing in the liver of patients. We screened several compound libraries against P. vivax liver stages, including 1565 compounds against mature hypnozoites, resulting in one drug-like and several probe-like hits useful for investigating hypnozoite biology.

Detection of diverse 16S rRNA sequences at low titers from malaria vectors in Kayin state, Myanmar.

Natural infections in malaria mosquitoes were recently reported in Africa, and negatively correlated with the development of in the vectors. The occurrence and effects of infections outside Africa have not been described and may have been underestimated. Mosquitoes were collected by human-landing catch during May and June 2017 in ten villages in Kayin state, Myanmar.

Insecticide resistance in malaria vectors along the Thailand-Myanmar border.

Background: There is a paucity of data about the susceptibility status of malaria vectors to Public Health insecticides along the Thailand-Myanmar border. This lack of data is a limitation to guide malaria vector-control in this region. The aim of this study was to assess the susceptibility status of malaria vectors to deltamethrin, permethrin and DDT and to validate a simple molecular assay for the detection of knock-down resistance (kdr) mutations in the study area.