Chromosomal abnormalities study for anembryonic pregnancy by BACs-on-Beads technique.

Objective: This study evaluated the BACs-on-Beads™ (BoBs) efficiency assay in detecting chromosomal anomalies in products of conception (POC) specimens associated with anembryonic pregnancy (AP) among Thai pregnant women.

Method: Retrospective analysis applied the BoBs™ assay to examine AP samples from 2010 to 2022. The incidences of AP with chromosomal abnormalities were reported.

Committed change of real-time quantitative PCR to droplet digital PCR for monitoring :: transcripts in tyrosine kinase inhibitor treated CML.

Objectives: We performed a feasibility study of an FDA-approved commercial ddPCR assay to measure :: in CML patients treated using TKI therapy.

Methods: Assay performance of standard RQ-PCR and commercially available FDA-approved ddPCR were compared to measure :: p210 transcripts in RNA samples from 100 CML patients who received TKI therapy.

Results: %::/ levels obtained from both methods were not statistically significant difference after normalization with batch-specific conversion factor ( = 0.

Incidence and Types of Fetal Chromosomal Abnormalities in First Trimester of Thai Pregnant Women between Miscarriages and Intrauterine Survivals.

Abortion is a common pregnancy complication. Fetuses with several types of chromosomal abnormalities are aborted during the first trimester, while others have a better chance of surviving. This research aims to study and compare the incidence and types of fetal chromosomal abnormalities during the first trimester of Thai pregnant women between miscarriages and intrauterine survivals.

Performance of the MLPA technique for detecting common mutations in Leber hereditary optic neuropathy.

Leber hereditary optic neuropathy (LHON) causes painless vision loss resulting from mitochondrial DNA (mtDNA) mutation. Over 95% of LHON cases result from one of three mtDNA point mutations (m.3460G>A, m.

Characterization of five complete mitogenome structures reveals low structural diversity and conservation of repeated sequences in the lineage.

Mitochondrial genomes (mitogenomes) of five were determined. Their compositions and structures were similar to most of the available gecko lizard mitogenomes as 13 protein-coding, two rRNA and 22 tRNA genes. The non-coding control region (CR) of almost all mitogenome structures contained a repeated sequence named the 75-bp box family, except for which contained the 225-bp box.