Mallotumides A-C: Potent Cytotoxic Cycloheptapeptides from the Roots of .

The structures of potent cytotoxic cycloheptapeptides, mallotumides A-C (-, respectively) isolated from the roots of Airy Shaw, were elucidated by extensive spectroscopic analysis. The absolute configuration of was determined by single-crystal X-ray crystallographic data. All three cycloheptapeptides exhibited potent cytotoxicity against various cancer cell lines with IC values ranging from 0.

Mass spectral analysis of secondary metabolites from Zingiber montanum rhizome extract using UHPLC-HR-ESI-QTOF-MS/MS.

Introduction: Zingiber montanum (J.Koenig) Link ex A.Dietr.

Acute and subchronic oral toxicity studies of Nelumbo nucifera stamens extract in rats.

Ethnopharmacological Relevance: Since the use of Nelumbo nucifera stamens in herbal medicines as well as in cosmetic products are highly prevalent in Thailand and increasing worldwide, acute and subchronic toxicity studies to confirm the safe use of Nelumbo nucifera stamens are warranted.

Aim Of The Study: Acute and subchronic oral toxicity studies of Nelumbo nucifera stamens extract in rats were performed in the present study in order to evaluate its safety.

Materials And Methods: In acute toxicity study, Nelumbo nucifera stamens extract was administered by oral gavage to Sprague-Dawley rats (5 males and 5 females) at a dose of 5000 mg/kg.

A novel cycloheptapeptide exerts strong anticancer activity via stimulation of multiple apoptotic pathways in caspase-3 deficient cancer cells.

Background: VR3848 is a novel cycloheptapeptide, isolated from a Euphorbiaceae plant, which can suppress proliferation of various tumor cells at nanomolar concentration. Due to its novelty and potency, the molecular process of tumor cell growth inhibition was investigated intensively.

Materials And Methods: MCF-7 cells, a caspase-3 deficient cancer cell line, were treated with VR3848.