Publications by authors named "Prannay Reddy"
Article Synopsis
- The mechanisms behind emotional responses to chronic pain are not well understood.
- In mice with chemotherapy-induced peripheral neuropathy (CIPN), licking affected areas becomes a strong coping mechanism, especially in response to cold stimuli.
- Research identified the lateral parabrachial nucleus (LPBN) as crucial in managing this licking behavior by responding to pain signals from the spinal cord and brain, highlighting the complex interaction between pain and emotional responses.
Itch is a unique sensory experience that is responded to by scratching. How pruritogens, which are mechanical and chemical stimuli with the potential to cause itch, engage specific pathways in the peripheral and central nervous system has been a topic of intense investigation over the last few years. Studies employing recently developed molecular, physiological, and behavioral techniques have delineated the dedicated mechanisms that transmit itch information to the brain.
View Article and Find Full Text PDFObjectively measuring animal behavior is vital to understanding the neural circuits underlying pain. Recent progress in machine vision has presented unprecedented scope in behavioral analysis. Here, we apply DeepLabCut (DLC) to dissect mouse behavior on the thermal-plate test - a commonly used paradigm to ascertain supraspinal contributions to noxious thermal sensation and pain hypersensitivity.
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