Publications by authors named "Pranita Paudyal"
Article Synopsis
- Fibroblast activation protein (FAP) is found in cancer-associated fibroblasts and is linked to poor cancer outcomes; PET/CT imaging using FAPI (radiolabeled FAP inhibitors) is being explored for diagnosing various cancers.
- FAPI PET/CT outperforms F-fluorodeoxyglucose ([F]FDG) in many cases due to better tumor-to-background contrast, improved specificity for certain metastases, and enhanced sensitivity for identifying disease spread.
- Despite its advantages, FAPI has challenges such as non-specific uptake in some situations, variations with age/menopause, limited clinical accessibility, and a lack of extensive clinical data supporting its use.
Article Synopsis
- F-fluorodeoxyglucose (FDG) and F-sodium fluoride (NaF) are new PET tracers used to evaluate inflammation in atherosclerosis and the calcification process, respectively.
- FDG has been utilized for years to assess heart viability and is now important in diagnosing cardiac sarcoidosis, while PET techniques can also help identify early signs of atherosclerosis to inform interventions.
- NaF-PET/CT is emerging as a more effective method than FDG for monitoring plaque formation and can reveal coronary artery disease that FDG imaging may miss due to normal heart activity interference.
Background: Tumor budding is a significant prognostic indicator for poor survival of several solid tumors. However, due to the lack of a standard scoring system, its clinical application for biliary tract cancer (BTC) is limited.
Objective: To identify the prognostic significance of tumor budding in BTC.
Background: The use of laparoscopic liver resection for curative surgery of intrahepatic cholangiocarcinoma (ICC) is not well established. Herein, we perform a meta-analysis to compare the differences between laparoscopic liver resection (LLR) and open liver resection (OLR) for ICC.
Methods: Multiple electronic databases were searched and 8 relevant studies containing 552 patients treated by LLR and 2320 treated by OLR were identified.