Cortical Gray Matter Volume Associations with Dietary Fiber and Calorie Density: A Pilot Study.

Alzheimer's disease and related dementia are associated with significant societal costs and economic burdens and have been associated with decreases in cortical gray matter volume. This pilot cross-sectional study investigates the relationship between total fiber concentration in diet, total calorie density per diet, and regional GMV in a cohort of 190 patients aged 20 to 79 years, utilizing data from the 2015 National Health Interview Survey Supplement and T1-weighted magnetic resonance imaging (MRI) collected at the McCausland Center for Brain Imaging. Gray matter volumes were quantified using the CAT12 voxel-based morphometry toolbox and statistical correlations between GMV and dietary measures were assessed using Spearman's rank order correlation coefficient.