Hydrogeochemical investigation and water quality assessment of the Indus River in the semiarid region of Ladakh, India.

The decline in water quality, particularly in river water, is a significant concern, especially in semi-arid areas and tourist destinations such as Ladakh. Periodic assessment of water quality could be a crucial step for ensuring its potability and serve as a foundation for formulating effective policies for sustainable water resource management. Consequently, this research aimed to analyze the periodic variations in the water quality of Indus River for domestic and agricultural use, focusing on the impact of geochemical processes within the basin.

In situ chlorpyrifos (CPF) degradation by Acrobeloides maximus: Insights from chromatographic analysis.

The objective of this study was to evaluate the efficiency of nematodes in zooremediation of chlorpyrifos (CPF), an organophosphate pesticide. The nematode population Acrobeloides maximus (A. maximus) was employed for bioremediation, converting CPF into non-toxic residues.

Visible light mediated synthesis of 1,3-diarylated imidazo[1,5-]pyridines oxidative amination of C-H catalyzed by graphitic carbon nitride.

Graphitic carbon nitride (g-CN) as a novel heterogeneous catalyst is employed for the visible light-mediated synthesis of the imidazo[1,5-]pyridines the oxidative amination of C-H bond at room temperature without the need for any additional solvent. Extensive characterization of the catalyst was performed using techniques such as FT-IR, PXRD, TGA, SEM and EDX analysis. The optimized conditions enabled the successful and expeditious conversion of a wide range of substrates to imidazo[1,5-]pyridines in good yields; a notable advantage of this catalyst being recyclability, as it can be reused for up to five cycles without significant loss of activity.

Green synthesis of silver nanoparticles using Adhatoda vasica leaf extract and its application in photocatalytic degradation of dyes.

The paper describes biogenic synthesis of silver nanoparticles (AgNPs) using Adhatoda vasica leaf extracts at room temperature. The prepared AgNPs were characterized by UV-visible spectroscopy, Fourier-transform infrared spectroscopy, powder X-ray diffraction, Energy dispersive X-ray (EDX), High Resolution Transmission Electron Microscope, Scanning Electron Microscopy and Thermogravimetric analyser. The bio reduction method is devoid of any toxic chemicals, organic solvents, and external reducing, capping and stabilizing agent.

Progress in appended calix[4]arene-based receptors for selective recognition of copper ions.

In the past two decades, there has been significant progress in the design and development of synthetic receptors for molecular recognition as they find application in the field of chemical, biological, medical, and environmental sciences. Synthetic receptors based on calix systems appended with fluorogenic and chromogenic groups have gained considerable attention for sensing and recognition of ions and molecules. Copper (Cu) is an essential element required in trace amounts in all living organisms to carry out various biological processes.

Bioprospecting phytochemicals of Rosmarinus officinalis L. for targeting SARS-CoV-2 main protease (M): a computational study.

Context: The persistent spread of highly contagious COVID-19 disease is one of the deadliest occurrences in the history of mankind. Despite the distribution of numerous efficacious vaccines and their extensive usage, the perpetual effectiveness of immunization is being catechized. Therefore, discovering an alternative therapy to control and prevent COVID-19 infections has become a top priority.

A New Conformationally Symmetrical Calix[4]pyrrole Based Supramolecular System for Liquid Crystalline and Window Layer Solar Cell Applications.

The newly symmetrical liquid crystalline compounds (CPB -CPB ) based on calix[4]pyrrole as central rigid core are synthesized via esterification reaction. All the four functionalized compounds exhibit columnar hexagonal phase (Col ) over a higher mesophase temperature range and further stabilized mesophase upto room temperature. The thermal behavior and optical texture are identified by using differential scanning calorimetry (DSC), Polarizing optical microscopy (POM) while the molecular organization of compound in mesogenic state by X-ray diffraction technique.

Fucoidan, a brown seaweed polysaccharide in nanodrug delivery.

Fucoidan-a sulfated marine seaweed obtained from brown algae-has raised considerable interest in the scientific community over the last decade as it possesses a wide range of biological activities such as antioxidant, antiviral, anti-inflammatory, anticoagulant, antithrombotic, anticarcinogenic, and immunoregulatory. This polysaccharide finds application as a drug delivery vehicle due to its non-cytotoxicity, biocompatibility, and biodegradability. Besides, nano biomedical systems have used this marine alga for diagnostic and therapeutic purposes.

Thiacalixarene Appended Azo-based Supramolecular Systems: Self-assembly and Photo Tuning Reversible Liquid Crystalline Properties.

Four new azo-based supramolecular materials containing thiacalixarene core substituted by variable alkoxy groups (TFA -TFA ) have been designed and synthesized for the mesomorphic and photoswitching properties. The liquid crystalline behavior were accomplished by using DSC, POM, and XRD studies. All azo-based thiacalixarene based materials with short and higher chain length display columnar hexagonal mesophase with broad temperature range.

Preparation and optimization of tetraethyl orthosilicate cross-linked chitosan-guar gum-poly(vinyl alcohol) composites reinforced with montmorillonite for sustained release of sitagliptin.

Development of efficient drug carriers has become an integral part of advanced drug delivery systems. This work aims at developing composites by adopting an economically viable method for sustained release of anti-diabetic drug sitagliptin - a potent and selective dipeptidyl peptidase-IV inhibitor. To combat the harsh environment of gastrointestinal tract, the composite (F13) was prepared using biodegradable polymers namely chitosan, guar gum and poly(vinyl alcohol) with montmorillonite clay as nano-filler and tetraethyl orthosilicate as the cross linker.

Calixarene Functionalized Supramolecular Liquid Crystals and Their Diverse Applications.

Liquid crystals are considered to be the fourth state of matter with an intermediate order and fluidity in comparison to solids and liquids. Calixarenes are among one of the most versatile families of building blocks for supramolecular chemistry due to their unique vaselike structure that can be chemically engineered to have different shapes and sizes. During the last few decades, calixarenes have drawn much attention in the field of supramolecular chemistry due to their diverse applications in the fields of ion and molecular recognition, ion-selective electrodes for catalysis, drug delivery, gelation, organic electronics and sensors, etc.

A Status Update on the Development of Polymer and Metal-Based Graphene Electrochemical Sensors for Detection and Quantitation of Bisphenol A.

The detection and quantitation of bisphenol A (BPA) in the environment and food products has been a subject of considerable interest. BPA, a diphenylmethane derivative is a well-known industrial raw material with wide range of applications. It is a well-known endocrine disruptor and acts as an estrogen mimic.

Hybrid solid-phase extraction to overcome interference due to phospholipids for determination of neratinib in human plasma using UPLC-MS/MS.

A reliable and robust bioanalytical method was developed to quantify neratinib, a tyrosine kinase inhibitor in human plasma, using UPLC-MS/MS. The extraction of neratinib and its deuterated internal standard, neratinib-d6, was successfully performed on hybrid solid-phase extraction ultra-cartridges to remove the interference of phospholipids and proteins. Chromatographic analysis was performed on a UPLC BEH C18 (50 × 2.

Simultaneous enantioseparation and simulation studies of atenolol, metoprolol and propranolol on Chiralpak® IG column using supercritical fluid chromatography.

Enantioseparation of three β-blockers, i.e., atenolol, metoprolol and propranolol, was studied on amylose tris(3-chloro-5-methylphenylcarbamate) immobilized chiral stationary phase using supercritical fluid chromatography (SFC).

Photodynamic therapy with light emitting fabrics: a review.

Photodynamic therapy is a powerful tool in the localized and selective treatment of dermatologic diseases, such as actinic keratosis, acne vulgaris, Bowen's disease and basal cell carcinoma. The success of photodynamic therapy is mainly attributed to the development of flexible light sources for homogenous and reproducible illumination during clinical studies. The essential requirement for this therapy includes, a suitable photosensitizer, presence of oxygen and a light of specific wavelength and intensity.

Application of supercritical fluid chromatography for separation and quantitation of 15 co-formulated binary anti-hypertensive medications using a single elution protocol.

A facile supercritical fluid chromatography method is proposed to analyse 15 co-formulated binary anti-hypertensive drug combinations using a customized elution procedure. The effect of mobile phase composition, column back pressure and temperature was suitably optimized for adequate retention, analyte response and resolution. The chromatographic separation of the different drug combinations was performed on a DCPak poly(4-vinylpyridine) column (250 × 4.

Analytical separation of four stereoisomers of luliconazole using supercritical fluid chromatography: Thermodynamic aspects and simulation study with chiral stationary phase.

The work describes a novel supercritical fluid chromatography method for the separation of four stereoisomers, RZ(+), SZ(-), RE(+) and SE(-) of luliconazole, an antifungal agent on amylose tris[(S)-α-methylbenzyl carbamate] based Chiralpak IH column. The effect of organic modifiers (methanol, ethanol and isopropanol), column temperature and back pressure were evaluated for their selective separation. A consistent elution order, RZ(+) > SZ(-) > RE(+) > SE(-) was observed in all the modifiers.

Separation of achiral anti-diabetic drugs using sub/supercritical fluid chromatography with a polysaccharide stationary phase: Thermodynamic considerations and molecular docking study.

A simple, fast and environmental friendly supercritical fluid chromatography-photodiode array (SFC-PDA) method was developed for the simultaneous determination of metformin and three sodium-glucose co-transporter 2 (SGLT-2) inhibitors (canagliflozin, dapagliflozin and empagliflozin). The impact of different stationary phases, co-solvents, column temperature and outlet pressure was extensively evaluated for selective separation and quantitation of the drugs. Amongst several achiral and chiral stationary phases tested, the best results were obtained on amylose based Chiralpak IG column using CO and 0.

Selective quantification of lacosamide in human plasma using UPLC-MS/MS: Application to pharmacokinetic study in healthy subjects with different doses.

A practical, sensitive, and robust UPLC-MS/MS method was developed and validated to quantify lacosamide in human plasma. A simple one-step protein precipitation was used to extract lacosamide and labeled lacosamide-13C, D3 as an internal standard (IS) from 150-μL plasma. The extracts were analyzed on an Eclipse Plus C18 column (50 × 2.

Dual Fluorescence-colorimetric Silver Nanoparticles Based Sensor for Determination of Olanzapine: Analysis in Rat Plasma and Pharmaceuticals.

The present work describes a dual-readout assay for the determination of an antipsychotic drug olanzapine using Rhodamine B modified silver nanoparticles (AgNPs). AgNPs, when mixed with Rhodamine B, quenched its fluorescence emission with high quenching efficiency as evident from the Stern Volmer plot. Transmission electron microscopy image and Dynamic Light Scattering histogram of Rhodamine B bound AgNPs showed a stable monodispersed nanosuspension.

Assessment of contaminants in the northwestern Bay of Bengal.

The coastal sediments in the northern Bay of Bengal has undergone contamination due to the heavy metal contribution from rivers. To evaluate the status of contamination in the inner shelf region of the Bay of Bengal, a sediment core chronologically constrained using Pb dating technique from the northwest Bay of Bengal was investigated for several trace elements. To assess sediment quality, enrichment factor (EF), geo-accumulation index (Igeo), and Modified Nemerow Pollution Index (MPI) were derived.

Modulation of inner filter effect of non-conjugated silver nanoparticles on blue emitting ZnS quantum dots for the quantitation of betahistine.

A simple, reliable and efficient fluorescent probe has been developed for the detection and quantitation of betahistine using inner filter effect (IFE) of silver nanoparticles (AgNPs) on zinc sulphide (ZnS) quantum dots. The synthesized ZnS exhibited blue emission at 403 nm which was quenched upon mixing with AgNPs due to intensive localized surface plasmon resonance (LSPR) absorption at 401 nm. The presence of IFE was confirmed by UV-Visible and fluorescence spectroscopy, dynamic light scattering and transmission electron microscopy.