Cyclooxygenase-2 interacts with MMP and FGF pathways to promote epimorphic regeneration in lizard Hemidactylus flaviviridis.

Cyclooxygenase-2 (COX-2) is an inducible enzyme known for its role in promoting inflammation, pain and cancer. It has more recently been attributed a function in epimorphic regeneration of vertebrate appendages. However, its position among the molecular regulators of regeneration remains unclear.

COX-2 activity and expression pattern during regenerative wound healing of tail in lizard Hemidactylus flaviviridis.

Cyclooxygenase-2 (COX-2) is an important mediator of the immune response. It is found upregulated after pathogen invasion or tissue injury and also in many cancers. Of the lesser known functions of this enzyme is its role in effecting epimorphic regeneration.

Inhibition of Cyclooxygenase-2 Alters Wnt/β-Catenin Signaling in the Regenerating Tail of Lizard .

Epimorphic regeneration in vertebrates involves the restoration of lost tissue or organs through the formation of a regeneration blastema and occurs through a complex interaction of a number of molecular signaling pathways. Of the many effectors of successful tail regeneration in the lizard , one crucial pathway is the cyclooxygenase-2 (COX-2) mediated PGE signaling pathway. The current study was aimed at understanding whether COX-2 signaling plays any role in the expression of Wnt/β-Catenin signaling components during regenerative outgrowth in .