Cell spheroid viscoelasticity is deformation-dependent.

Tissue surface tension influences cell sorting and tissue fusion. Earlier mechanical studies suggest that multicellular spheroids actively reinforce their surface tension with applied force. Here we study this open question through high-throughput microfluidic micropipette aspiration measurements on cell spheroids to identify the role of force duration and spheroid deformability.

Engaging Chief Medical Officers to Improve Multidisciplinary Rounds.

Background: Multidisciplinary rounds (MDRs), a model of care in which multiple members of the care team, representing different disciplines, come together to discuss the care of a patient in real-time. MDRs are a valuable tool for clinical teams to improve patient length of stay (LOS), reduce healthcare-associated infections, and increase care coordination. HCA Healthcare's data science and performance improvement teams created a data visualization tool called Next-gen Analytics for Treatment and Efficiency (NATE) Tempo to support care teams in managing rounds and barriers.

Performance investigation of a modified single-basin solar distiller by augmenting thermoelectric cooler as an external condenser.

Harvesting freshwater from saline and seawater using solar energy has proven a significant impact in recent times. The present study aims to investigate the performance of the solar desalination system by incorporating glass reflectors, heat storage media, and a thermoelectric cooling system with a single-basin-type distiller. Accordingly, the objective of the study is to improve the performance of the solar distiller in terms of freshwater production and efficiency compared to a conventional setup.

Impact of Adherence to a Standardized Oxytocin Induction Protocol on Obstetric and Neonatal Outcomes.

Background: Oxytocin protocols are employed to induce uterine contractions and progressive cervical changes, but they are associated with adverse maternal and neonatal outcomes. The aim of this study was to determine whether compliance with a checklist-based protocol for oxytocin administration was associated with changes in neonatal and maternal outcomes.

Methods: A retrospective cohort study of 86,786 pregnant women undergoing term (> 37 weeks) induction of labor between January 2015 and December 2017 was performed.

Extracellular fluid viscosity enhances cell migration and cancer dissemination.

Cells respond to physical stimuli, such as stiffness, fluid shear stress and hydraulic pressure. Extracellular fluid viscosity is a key physical cue that varies under physiological and pathological conditions, such as cancer. However, its influence on cancer biology and the mechanism by which cells sense and respond to changes in viscosity are unknown.

Performance improvement and advancement studies of mixed-mode solar thermal dryers: a review.

Solar thermal dryers are solar-operated gadgets utilized to dehumidify various products, especially food items and rubber sheets. This article provides detailed design, parametric studies, and an in-depth review of mixed-mode solar dryers (MMSD) with a case study of fish drying near coastal lines. Due to several advantages compared to open sun drying and prominent performance index compared to indirect and direct type solar dryers, mixed-mode solar dryers have large adaptability on the field.

Microfluidics meets 3D cancer cell migration.

An early step of metastasis requires a complex and coordinated migration of invasive tumor cells into the surrounding tumor microenvironment (TME), which contains extracellular matrix (ECM). It is being appreciated that 3D matrix-based microfluidic models have an advantage over conventional in vitro and animal models to study tumor progression events. Recent microfluidic models have enabled recapitulation of key mechanobiological features present within the TME to investigate collective cancer cell migration and invasion.

Visualizing Dynamic Changes During TGF-β-Induced Epithelial to Mesenchymal Transition.

Epithelial to mesenchymal transition (EMT) is crucial during embryonic development, tissue fibrosis, and cancer progression. Epithelial cells that display a cobblestone-like morphology can undergo a switch to mesenchymal-like phenotype, displaying an elongated spindle shape or a fibroblast-like morphology. EMT is characterized by timely and reversible alterations of molecular and cellular processes.

Performance assessment of conventional solar desalination system in Northern part of Gujarat.

Water distillation by utilising free energy from the sun is one of the significant techniques for getting freshwater from salty and seawater. For the remote areas and small societies where freshwater is distant, solar distillation is one of the best explanations for freshwater creation. The main objective of this study is to evaluate the performance of the flat plate collector-assisted conventional solar still incorporating mirror wall and heat storage material, which was tested at Anchor institute of solar energy studies, Mehsana (23.

COVID-19-Induced New-Onset Diabetes: Trends and Technologies.

The coronavirus disease 2019 (COVID-19) global pandemic continues to spread worldwide with approximately 216 million confirmed cases and 4.49 million deaths to date. Intensive efforts are ongoing to combat this disease by suppressing viral transmission, understanding its pathogenesis, developing vaccination strategies, and identifying effective therapeutic targets.

Drug resistance among extrapulmonary TB patients: Six years experience from a supranational reference laboratory.

Background & Objectives: There is limited information available about the drug resistance patterns in extrapulmonary tuberculosis (EPTB), especially from high burden countries. This may be due to difficulty in obtaining extrapulmonary specimens and limited facilities for drug susceptibility testing. This study was undertaken to review and report the first and second-line anti-TB drug susceptibility patterns in extrapulmonary specimens received at the National Institute for Research in Tuberculosis (NIRT), Chennai, India, between 2005 and 2012.