A randomized, phase 2, dose-ranging study in the treatment of moderate to severe inflammatory facial acne vulgaris with doxycycline calcium.

Background: Doxycycline calcium (WC2055) is a drug substance with a possible role in the treatment of acne. The objective of this study was to evaluate the safety and efficacy of three doses of doxycycline calcium tablets compared with placebo in the treatment of moderate to severe inflammatory facial acne vulgaris.

Methods: This was a randomized, double-blind, phase 2 dose-ranging study in subjects with moderate to severe inflammatory acne aged 12 years to 45 years.

Clinical spectrum and severity of psoriasis.

Psoriasis is a chronic inflammatory skin disease. Associated comorbidities or risks may include psoriatic arthritis, obesity, depression, smoking, diabetes, hyperlipidemia, an increased risk of cardiovascular disease with myocardial infarction, or an increased risk of lymphoma. The clinical presentation of psoriasis can range from the more common red scaling elevated plaques on the elbows, knees, or scalp to the less common superficial pustules scattered on the palms or soles, or in rare cases wide-spread pustules on the body.

A case of perforating necrobiosis lipoidica in an African American female.

An African American female with type II diabetes of 4 years duration presents with a 3-year history of smooth firm, dark brown plaques focally studded with comedone-like papules. Clinically and histologically her lesions were consistent with the rare entity perforating necrobiosis lipoidica.

Long-term management of generalized pustular psoriasis with infliximab: case series.

Background: Infliximab, a tumor necrosis factor alpha antagonist, has recently been shown to be successful for the short-term treatment of generalized pustular psoriasis (GPP) in multiple case reports.

Objective: The goal of this case series was to assess the efficacy of the longer-term management of GPP with infliximab.

Methods: Three patients with severe GPP were followed to assess the efficacy of long-term treatment with infliximab.

Perianal ulcerations from topical steroid use.

Topical steroids play an extremely important role in the treatment of various dermatologic conditions. Use of topical steroids must be approached with caution, however, as they can have serious side effects. We report a case of iatrogenic perianal ulcers caused by twice-daily application of Lotrisone (clotrimazole and betamethasone dipropionate) in the perianal region.

An eruption secondary to intravenous immunoglobulin therapy.

A 42-year-old woman presented with a recurrent eruption over the distal extremities. Lesions formed a few days after initiation of intravenous immunoglobulin (IVIg) therapy and lasted 2 to 3 weeks after therapy completion. Results of a histologic examination revealed parakeratosis, exocytosis, and spongiosis.