An Experimental Study to Evaluate the Antidepressant Effect of Zileuton and Aqueous Extract of Phyllanthus emblica in Unpredictable Chronic Mild Stress-Induced Depression in Albino Mice.

Introduction: Oxidative stress and proinflammatory signaling in the brain have been found to have a significant role in the pathogenesis of depression. Therefore, drugs that reduce oxidative stress and neuroinflammation may be helpful in depression as monotherapy or as an adjunct to conventional antidepressants. Zileuton, a 5-lipoxygenase inhibitor, has been identified as a putative antidepressant in an in vitro study.