Publications by authors named "Pranali N Shah"
Article Synopsis
- Delays in drug hypersensitivity reactions can lead to serious health issues, and the role of different T cell types in these reactions needs to be better understood.* -
- Research used advanced methods to compare skin-resident memory T cells (TRMs) and other T cell subsets in severe conditions like Stevens-Johnson syndrome (SJS) and drug reactions with eosinophilia (DRESS), versus milder conditions like morbilliform drug eruption (MDE).* -
- Results showed that TRMs play a significant role in skin-limited diseases, while SJS/TEN and DRESS involved more recruitment of cytotoxic CD8+ T cells, highlighting different immune responses and suggesting new directions for treatment and understanding of
The vitamin D receptor (VDR) is critical in regulating intestinal homeostasis and emerging evidence demonstrates that VDR deficiency is a critical factor in inflammatory bowel disease pathology. However, no clinical data exist regarding the intestinal expression of VDR in patients after allogeneic haematopoietic stem cell transplantation (HSCT). Analyzing intestinal biopsies from 90 patients undergoing HSCT with mortality follow-up, we demonstrated that patients with severe acute gastrointestinal graft versus host disease (GI-GvHD) showed significant downregulation of VDR gene expression compared to mild or no acute GI-GvHD patients (p = 0.
View Article and Find Full Text PDFDelayed-type drug hypersensitivity reactions (dtDHR) are immune-mediated reactions with skin and visceral manifestations ranging from mild to severe. Clinical care is negatively impacted by a limited understanding of disease pathogenesis. Though T cells are believed to orchestrate disease, the type of T cell and the location and mechanism of T cell activation remain unknown.
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