Desmogleins: hair perspective.

Desmogleins (Dsgs) are calcium-dependent, transmembrane glycoproteins belonging to the desmosomal cadherin superfamily, which play significant roles in selective calcium ions (Ca(2+)) dependent adhesion interactions between cell surfaces. Four subtypes of Dsg have been identified. Recent observations show the distribution of Dsgs can correlate with specific types of keratinization, anchorage of the hair, and hypotrichosis.

Twenty Nail Dystrophy with Pterygium Unguis.

A 15 year old female developed twenty nail dystrophy I at the age of 7 years, with formation of pterygium. There was no associated skin, mucous membrane, hair or other ectodermal abnormality. It is considered that lichen planus may be responsible for this condition.