Publications by authors named "Prakhar Y Shah"
Type VII secretion systems are membrane-embedded nanomachines used by Gram-positive bacteria to export effector proteins from the cytoplasm to the extracellular environment. Many of these effectors are polymorphic toxins comprised of an N-terminal Leu-x-Gly (LXG) domain of unknown function and a C-terminal toxin domain that inhibits the growth of bacterial competitors. In recent work, it was shown that LXG effectors require two cognate Lap proteins for T7SS-dependent export.
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- Bacterial type VIIb secretion systems (T7SSb) are protein complexes in Firmicutes that secrete toxic proteins, helping bacteria compete and cause disease.
- The study investigates domains of unknown function (DUFs) that are often found alongside LXG effector genes, revealing that these DUFs help target the effectors for export.
- Structural analyses show similarities between these DUFs and established T7SS effectors, highlighting a specific motif crucial for the secretion process of LXG effectors.