Publications by authors named "Prakash Rajappan"
Article Synopsis
- Some types of breast cancer, like triple-negative breast cancer (TNBC), have issues with finding good treatment targets and show different ways they grow and behave.
- Researchers studied a protein called galectin-3 in breast cancer tissues and found that higher levels of it are linked to more serious tumors and could help explain why some tumors resist treatment.
- They discovered that galectin-3 often works together with another protein called vimentin, and when both are present, they help cancer cells survive, spread, and grow more aggressively in TNBC patients.
DEPTOR is an endogenous inhibitor of mTOR complexes, de-regulated in cancers. The present study reveals a vital role for DEPTOR in survival of cervical squamous cell carcinoma (SCC). DEPTOR was found to be overexpressed in both cervical SCC cells and tissues and it's silencing in cervical SCC cells induced apoptosis, mainly by up-regulation of p38 MAPK and by inhibiting PI3K/AKT pathway via a feed-back inhibition from mTORC1-S6K.
View Article and Find Full Text PDF