Publications by authors named "Prakash Kumar Mishra"
Since there is lack of up to date consensus exists as to whether group training is effective in improving lumbopelvic pain (LPP) after pregnancy, a review of the recent evidences is needed. To determine the effect of group exercise training for the management of LPP among pregnant women compared with usual antenatal care. An electronic database search for relevant randomized control trials published in English from 2006 to 2015 was conducted.
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- Glioblastoma multiforme has a poor prognosis and urgent need for new treatment strategies has led to investigating the farnesyltransferase inhibitor manumycin, which induces apoptosis in glioma cells through increased reactive oxygen species (ROS).
- Manumycin's effect on glioma cells is demonstrated to be linked to a reduction in antioxidants like superoxide dismutase (SOD-1) and thioredoxin (TRX-1), and blocking ROS effectively prevents the apoptosis caused by manumycin.
- This research highlights that manumycin not only inhibits Ras activity but also affects crucial signaling pathways involved in glioma cell survival, opening doors for potential therapeutic strategies targeting ROS levels in glioblastoma treatment.