Publications by authors named "Prakash C Gupta"

Introduction: Adolescent overweight and obesity as measured by body mass index (BMI) seem to be increasing at an alarming rate in urban populations. Parental BMI plays an important role in their adolescent's BMI. Overweight and obesity coexisting with undernutrition in adolescents is an important public health challenge in low- and middle-income countries (LMICs).

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  • Smokeless tobacco and areca nut consumption significantly increases the risk of oral cancer, with an estimated 120,200 cases of oral cancer in 2022 attributed to these products globally, representing about 30.8% of all oral cancer cases.
  • The majority of these cases (77%) occurred in males, with the highest rates of attributable cases found in lower-middle-income countries and specific regions like Melanesia and Southcentral Asia.
  • The study highlights that effective control measures targeting smokeless tobacco and areca nut use could prevent a substantial number of oral cancer cases worldwide.
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Depression is a significant mental health challenge globally. While traditional antidepressants are effective, they often have unwanted side effects. Saffron, a natural spice derived from L.

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Background: The sale of loose cigarettes or bidis can undermine the purpose of requiring health warning labels (HWLs) on cigarette packs and bidi bundles by diminishing their visibility and legibility.

Objective: This mixed-methods study aims to examine the association between purchase behavior (loose vs pack or bundle), HWL exposure, and responses to HWLs among Indian adults who smoke.

Methods: Data were analyzed from the 2018-2019 India Tobacco Control Policy Survey and from 28 in-depth interviews conducted with Indian adults who smoked in 2022.

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  • - The rise in screen time among people, especially kids and teens, is linked to worries about its effects on brain health and neuroinflammation.
  • - Research indicates that too much digital media can disrupt sleep, lower cognitive engagement, and increase stress, potentially leading to inflammation in the brain.
  • - The review calls for more studies to understand the connections between screen time and neuroinflammation, aiming to help create guidelines for healthier media use.
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Background: India has the highest incidence worldwide of smokeless tobacco (SLT)-associated oral cancer, accounting for nearly 70% of all SLT users globally. Nicotine and tobacco-specific -nitrosamines (TSNA) play critical roles in the addictive and carcinogenic potential, respectively, of SLT products. Our group has previously reported substantial variability in nicotine and TSNA levels across a small SLT product sample in India, calling for systematic surveillance.

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  • The study aims to provide an overview of oral cancer (OC) in India, focusing on its epidemiology, risk factors, and advancements in prevention and treatment.
  • Major risk factors for OC identified include tobacco and areca nut use, with past interventions effectively reducing tobacco-related issues, but newer carcinogenic products on the rise.
  • Despite improvements in care, OC incidence is increasing due to low awareness about quitting harmful habits and the need for screening, highlighting the need for enhanced preventive strategies.
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Introduction: Banning the sales of loose cigarettes is recommended by Article 16 of the World Health Organization - Framework Convention on Tobacco Control. This study aims to understand the perceptions of cigarette users and tobacco vendors regarding such a ban.

Methods: Using a systematic recruitment and interview protocol, we interviewed cigarette users ( = 28) and tobacco vendors ( = 28) from two Indian cities where sales of loose cigarettes were banned (Mumbai) or not banned (Delhi).

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Background: Evidence suggests a possible link between diabetes and gastric cancer risk, but the findings remain inconclusive, with limited studies in the Asian population. We aimed to assess the impact of diabetes and diabetes duration on the development of gastric cancer overall, by anatomical and histological subtypes.

Methods: A pooled analysis was conducted using 12 prospective studies included in the Asia Cohort Consortium.

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  • * Using data from the Global Adult Tobacco Surveys, researchers found that Gutkha/paan masala users had higher exposure to media messages and warning labels, along with a greater likelihood of trying to quit compared to users of other products like oral tobacco.
  • * The findings suggest that tobacco control strategies need to be tailored based on SLT types, emphasizing the importance of effective communication to encourage quitting among less reached user groups.
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  • A study was conducted using data from 968,738 adults across 20 cohort studies in Asia to investigate the link between diabetes and liver cancer incidence and mortality.
  • The findings revealed that adults with diabetes had a significantly higher risk of being diagnosed with liver cancer (hazard ratio of 1.97) and dying from it (adjusted hazard ratio of 1.97) compared to those without diabetes.
  • The robust results, supported by a two-stage meta-analysis, contribute valuable evidence to the understanding of liver cancer risks among diabetic populations in Asian countries.
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  • Smokeless tobacco (SLT) health warning labels in India evolved from a single symbolic warning in 2009 to larger pictorial warnings covering 85% of packaging by 2016, and this study examined their effectiveness over time.
  • Despite the changes, the 2011 updates did not significantly improve warning effectiveness, but the larger warnings in 2016 increased awareness of health risks and the desire to quit SLT among users.
  • The findings indicate that while larger images led to some improved cognitive responses, the effectiveness of health warnings can diminish over time, showing the need for continued adaptation in warning designs.
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This paper presents the results of two proficiency testing (PT) rounds conducted by the Export Inspection Agency (EIA) Chennai laboratory in 2021 for food testing laboratories in India. The PT program was designed in accordance with ISO/TS 22117, a standard for proficiency testing in food microbiology, and targeted and as the organisms of focus. The samples were found to be stable and recoverable during the analysis, and all PT sample packages were delivered to participant laboratories in good condition.

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  • Body fatness is highlighted as a potential risk factor for biliary tract cancer (BTC), with established correlations between obesity and cholelithiasis (gallstones).
  • A comprehensive analysis of data from over 905,000 participants across 21 studies in Asia found that higher body mass index (BMI) correlates with increased BTC mortality, especially in females.
  • The study indicates that while obesity is linked to BTC mortality in women without gallstones, the relationship is less clear in men and when gallstones are present, suggesting complex interactions between BMI, gender, and gallstone presence.
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Introduction: Although lung cancer prediction models are widely used to support risk-based screening, their performance outside Western populations remains uncertain. This study aims to evaluate the performance of 11 existing risk prediction models in multiple Asian populations and to refit prediction models for Asians.

Methods: In a pooled analysis of 186,458 Asian ever-smokers from 19 prospective cohorts, we assessed calibration (expected-to-observed ratio) and discrimination (area under the receiver operating characteristic curve [AUC]) for each model.

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A randomised control trial was conducted among school teachers in Bihar, India for upscaling a tested, evidence-based tobacco intervention using train-the-trainer model. Six blocks in three districts were selected and randomised into intervention and control blocks. Cluster coordinators in intervention blocks were given training in the details of intervention.

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Background: This systematic review evaluated the available medical literature on the prevalence and trends of waterpipe tobacco smoking among adolescents and youth in jurisdictionally representative populations.

Methods: PubMed, Embase, and Scopus were searched for relevant studies from inception until 31 December 2022 that reported the burden of waterpipe smoking among adolescents and youth (10-24 years of age). We extracted qualitative data on the demographic characteristics, burden, and correlates of waterpipe smoking (PROSPERO ID: CRD42022310982).

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Introduction/objective: E-cigarette use poses an additional risk for individuals who are not cigarette smokers, especially adolescents. The marketing tactics of the industry have substantially increased the prevalence of e-cigarettes, use among adolescents. India banned e-cigarette in September 2019 that has been criticized by interested groups.

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Tobacco is a threat to public health in South-East Asia and its control should be a priority. However, many common assumptions about tobacco control may not hold true for the region and can misdirect policy. The substantial health risks associated with smokeless tobacco have been largely misunderstood and neglected.

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Background: Previous research in high-income countries (HICs) has shown that smokers reduce their cognitive dissonance through two types of justifications over time: risk minimizing and functional beliefs. To date, however, the relationship between these justifications and smoking behaviors over time has limited evidence from low- and middle-income countries. This study examines these of justifications and their relation to quitting behavior and intentions among smoking tobacco users in India.

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  • This study investigates how family functioning varies across different cultural contexts in urban India, focusing on adolescents aged 13 to 15 and their primary caregivers.
  • Data was collected from 843 families in Mumbai and 913 in Kolkata, using a survey that measured various dimensions of family dynamics, including communication and supervision.
  • Findings revealed that family functioning differs by demographics, with male adolescents reporting poorer family environments in Mumbai and higher socioeconomic status linked to better functioning; cultural factors, like religion and language, also influenced family dynamics.
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The South Asian region occupies a unique place in global tobacco control because of a broad spectrum of widely used tobacco products and the consequent mix of local and transnational tobacco industries. Cigarette use is especially high among males in many countries, while bidis are widely used in India, Bangladesh and Sri Lanka, and are very inexpensive. Smokeless tobacco use is a global problem, but the bulk of use is in South Asia and there is emerging promotion of newly developed tobacco and nicotine products across the region.

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Synopsis of recent research by authors named "Prakash C Gupta"

  • - Prakash C Gupta's recent research encompasses the global burden of oral cancer linked to smokeless tobacco and areca nut consumption, highlighting significant mortality rates and the need for targeted prevention strategies in key consuming countries.
  • - The author is actively investigating alternative therapeutic approaches for diseases such as depression through studies on natural interventions like saffron, while also examining the ramifications of tobacco consumption and related behaviors on public health, particularly in India.
  • - Gupta's work also delves into the health consequences of lifestyle factors, such as screen time and diabetes, and their connections to increased cancer risk, reinforcing the critical need for comprehensive health policies based on emerging epidemiological data.