A near infrared light activated phenothiazine based cancer cell specific phototherapeutic system: a synergistic approach to chemo-photothermal therapy.

In the pursuit of more effective cancer therapies, phototherapy has emerged as a promising approach due to its non-invasive nature and high precision. This study presents the development of a near-infrared (NIR) light-responsive phenothiazine (PTZ) based phototherapeutic system designed for targeted cancer treatment. This phototherapeutic system integrates four crucial elements for enhanced therapeutic efficacy: cancer cell-specific activity, mitochondrial targeting, photothermal conversion, and controlled drug release.

Comparison of Bond Strength of Metal and Ceramic Brackets with or without Primer.

Background: Bonding is an integral part of orthodontic treatment. Orthodontic bonding could be accomplished without the use of primer, it might be possible to reduce the risk of occupational exposure to primer and will save time. So it is very important to know whether primer is required or not.