Publications by authors named "Pragun G Rajbhandari"

Nepal's poultry industry has experienced remarkable growth in the last decade, but farm biosafety and biosecurity measures are often overlooked by farmers. As a result, farms often suffer from sporadic and regular outbreaks of many diseases, impacting production and creating public health challenges. Poor management practices, including overuse of antibiotics for prophylaxis and therapeutics, can enhance the spread of poultry diseases by propagating antimicrobial resistance (AMR) that is threatening poultry and human health.

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Canine distemper is a highly contagious, often fatal disease caused by canine distemper virus (CDV) in domestic dogs and wild carnivores. The virus has caused mass epidemics in both wild and captive carnivores of high conservation value such as tigers, lions and leopards. Hence, understanding and managing CDV outbreaks is particularly important in Nepal, which is home to many species of threatened wild carnivores including tigers, leopards, snow leopards, dholes and wolves, and also contains a large population of stray dogs.

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Understanding disease burden and transmission dynamics in resource-limited, low-income countries like Nepal are often challenging due to inadequate surveillance systems. These issues are exacerbated by limited access to diagnostic and research facilities throughout the country. Nepal has one of the highest COVID-19 case rates (915 cases per 100,000 people) in South Asia, with densely-populated Kathmandu experiencing the highest number of cases.

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Article Synopsis
  • Campylobacter spp. are underreported bacteria that can cause gastroenteritis in humans and are commonly found in animals like Rhesus macaques, especially in developing countries.
  • A study in Kathmandu analyzed 67 diarrheal samples from monkeys, finding Campylobacter spp. in 96% of them, with a specific focus on Candidatus Campylobacter infans and potential new sub-species.
  • The presence of these pathogens in both monkeys and environmental samples highlights the need for a One Health approach to control and prevent diarrheal outbreaks affecting both humans and animals.
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