Publications by authors named "Pragallabh Purwar"
ACS Pharmacol Transl Sci
June 2024
Article Synopsis
- T cells are essential for fighting tumors and clearing infected cells by recognizing specific targets through T-cell receptors (TCRs) that bind to pMHC molecules on these cells.
- Current methods for creating pMHC molecules may miss important TCRs that target weaker, yet effective peptides, making personalized immunotherapy challenging.
- A new method using sortase and click chemistry enables the stable generation of pMHC molecules, improving their binding to TCRs and offering a more effective approach to study and target antigen-specific T cells for cancer treatment.
