A novel electrochemical sensor based on ꞵ-cyclodextrin/bismuth oxybromide/multi-walled carbon nanotubes modified electrode with in situ addition of tetrabutylammonium bromide for the simultaneous detection and degradation of tebuconazole.

A novel electrochemical sensor-based glassy carbon electrode (GCE) was fabricated and applied to simultaneous detection and degradation of tebuconazole (TBZ) for the first time. The GCE was consecutively modified by multi-walled carbon nanotubes (MWCNTs), bismuth oxybromide (BiOBr), ꞵ-cyclodextrin (ꞵ-CD), and in situ addition of tetrabutylammonium bromide (TBABr). The detection was based on the decreasing of Bi signal at its anodic potential (E) of 0.

Antibacterial activity evaluation of vinyl sulfones against global predominant methicillin-resistant Staphylococcus aureus USA300.

The electrophilic potential of vinyl sulfone permits the rapid capture of cysteine-containing proteins under physiological conditions. These cysteine proteinases play vital roles in bacterial survival and pathogenesis of Staphylococcus aureus (S. aureus) and the global health threat methicillin resistant S.

New furan derivatives from fungus.

Two new furan derivatives, annulofurans A-B (-), together with six known compounds were isolated from fungus. The structures were determined based on NMR and mass spectrometry data. The absolute configurations of annulofurans A-B were determined by Electronic Circular Dichroism (ECD) experiment and comparisons with the experimental ECD spectra of synthesized stereoisomers.

Metabolic Changes of Cholangiocarcinoma Cells in Response to Coniferyl Alcohol Treatment.

Cholangiocarcinoma (CCA) is a major cause of mortality in Northeast Thailand with about 14,000 deaths each year. There is an urgent necessity for novel drug discovery to increase effective treatment possibilities. A recent study reported that lignin derived from can cause CCA cell inhibition.

Anti-inflammatory and cytotoxic agents from sp. SWUF09-62 fungus.

The ongoing search for anti-cancer agents from microorganisms led to the isolation of four new compounds including 6-ethyl-8-hydroxy-4-chromen-4-one (), 6-ethyl-7,8-dihydroxy-4-chromen-4-one (), (3)-3,4-dihydro-8-hydroxy-7-methoxy-3-methylisocoumarin () and (3)-3,4-dihydro-5,7,8-trihydroxy-3-methylisocoumarin (), together with eleven known compounds (-) from sp. SWUF09-62 fungus. The chemical structures were deduced from IR, 1D and 2D NMR, and MS data.

Iodine-catalyzed Sulfonylation of Arylacetylenic Acids and Arylacetylenes with Sodium Sulfinates: Synthesis of Arylacetylenic Sulfones.

A highly efficient and generally applicable iodine-catalyzed reaction of arylacetylenic acids and arylacetylenes with sodium sulfinates for the synthesis of arylacetylenic sulfones was developed. The methodology has the advantages of a metal-free strategy, easy to handle reagents, functional group tolerance, a wide range of arylacetylenic acids and arylacetylenes, and easy access to arylacetylenic sulfones.

PhI(OAc)2 mediated decarboxylative sulfonylation of β-aryl-α,β-unsaturated carboxylic acids: a synthesis of (E)-vinyl sulfones.

A highly efficient metal-free decarboxylative sulfonylation protocol for the preparation of (E)-vinyl sulfones from of β-aryl-α,β-unsaturated carboxylic acids using sodium sulfinates and (diacetoxyiodo)benzene (PhI(OAc)2) was developed. This strategy offers a simple and expedient synthesis of (E)-vinyl sulfones bearing a wide variety of functional groups. A radical-based pathway has been proposed for this decarboxylative sulfonylation reaction.

Regioselective C2 sulfonylation of indoles mediated by molecular iodine.

A facile and general method for regioselective C2 sulfonylation reaction of indoles mediated by iodine is described. The 2-sulfonylated products were obtained up to 96% yield under mild reaction conditions (room temperature, 2 h).