Publications by authors named "Pradeepkumar Bhupalam"
Aim: The present study aimed to compare the adherence to anti-TB treatment among post-COVID-19 pulmonary TB cases and TB patients without a history of COVID-19 in South India.
Methods: A prospective, cross sectional study was conducted in all drug-sensitive pulmonary tuberculosis patients in National TB Elimination Program. The research investigates the impact of the COVID-19 pandemic on TB management, considering both subjective and objective measures of adherence.
Inflammation and Stem Cell Stochasticity of HPV-induced Cervical Cancer: Epigenetics Based Biomarkers through Microbiome and Metabolome for Personalized Medicine: A Systematic Review.
Curr Med Chem
November 2023
Background: Chemoresistance by stemness in HPV-induced cervical carcinogenesis has significant implications for the overall disease-specific survival of the patients. To date, there are no reports related to the implications of significant aspects of inflammation and microbiome-- mediated epigenetics in cervical cancers.
Objective: The current systematic review delineates the significant aspects of the inflammation-related pathophysiology, cervical cancer diagnosis based on the HPV-indued stemness, and microbiome- mediated epigenetic markers to develop personalized therapies to target the stemness-acquired indefinitely dividing cancer stem cells.
Article Synopsis
- Vaccine hesitancy is identified as a major global public health threat by the WHO, and limited research exists in India that typically focuses on individual vaccines rather than overall hesitancy patterns.
- A study conducted in a NGO hospital in Andhra Pradesh involved 574 mothers of children under five, assessing vaccine hesitancy through interviews and reviewing vaccination records, with findings showing a hesitancy prevalence of 28.05%.
- Results indicated that lower parental education and fewer antenatal visits were associated with higher vaccine hesitancy, while higher socioeconomic status and awareness were linked to lower hesitancy rates, highlighting the influence of demographics and WHO-SAGE factors.
Article Synopsis
- Polypharmacy is common in managing conditions like diabetes and depression, with drugs often interacting due to shared metabolic pathways, specifically CYP450 enzymes.
- This study investigated how trazodone affects the pharmacokinetics and pharmacodynamics of pioglitazone in both normal and diabetic rat models, as well as in rabbits.
- The results showed that trazodone enhances the hypoglycaemic effects of pioglitazone by altering its metabolism, suggesting careful management when these drugs are used together.
Article Synopsis
- The study aimed to create ocular films containing Dexamethasone sodium phosphate (DSP) using specific polymers to control the drug release.
- The films were thoroughly tested for their physical properties and drug release both in lab conditions (in vitro) and in live rabbits (in vivo), showing consistent results.
- The final formulation (F-8) demonstrated stability under stress and effectively maintained DSP at the targeted site for an extended period, achieving the desired therapeutic effects.
Objectives: The main objective of the present study is to evaluate the mitigative effect of hydroalcoholic extract of fruits against sodium fluoride (NaF) induced hepatotoxicity.
Methods: In this study, Wistar male albino rats were randomly divided into five groups of six rats each. Group I and II served as normal and toxic controls.
Article Synopsis
- * A total of 2459 participants completed the survey, revealing that major information sources were television (74.5%) and social media (71.0%), with most respondents exhibiting good knowledge (74.7%) and practices (88.1%) toward COVID-19, but only 57.6% had the correct perception.
- * Findings indicate a need for educational programs to address misconceptions about COVID-19, as factors like age, education level, urban living, and healthcare profession were linked to better knowledge and practices.
Objectives: Chronic kidney failure among people with diabetes mellitus (DM) is a burgeoning health problem that affects up to 25% of patients with type 2 DM. Current pharmacological treatment for diabetic nephropathy (DN) does not stop the attainment of renal complications. The intention of the current study was to explore the role of a polyherbal formulation (PHF) in diabetic-induced nephropathy in experimental animals.
View Article and Find Full Text PDFIntroduction: is a rich source for phenols and the wood, leaves, and flowers of the plant are used as medicinal agents in traditional medicine. Peptic ulcer is a major disease of gastrointestinal tract, affecting nearly 40 lac people each year worldwide and affects 10% of world population with different aetiologies. consists of phenols and flavonoids, tannins which have potential antioxidant and cytoprotective activity.
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