Publications by authors named "Pradeep R Rajasekaran"

Gut-brain axis (GBA) communication relies on serotonin (5-HT) signaling between the gut epithelium and the peripheral nervous system, where 5-HT release patterns from the basolateral (i.e., bottom) side of the epithelium activate nerve afferents.

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Article Synopsis
  • A novel lithographic editing system is introduced, featuring a conically shaped hydrogel probe that can erase and correct nanoscale patterns in real time through optical feedback.
  • The hydrogel works like a "nanosponge," absorbing molecular patterns via diffusion, allowing for high-speed erasing rates (~785 μm/s) that significantly outperform traditional methods like atomic force microscopy.
  • The system facilitates precise molecular editing by integrating piezoelectric actuators with an optical microscope, enabling user-friendly writing, erasing, and rewriting, and demonstrating potential applications in fabricating advanced electronic devices like microphotodetectors.
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Large scale fabrication of non-linear microporous membranes is of technological importance in many applications ranging from separation to microfluidics. However, their fabrication using traditional techniques is limited in scope. We report on fabrication and characterization of non-linear parabolic micropores (PMS) in polymer membranes by utilizing flow properties of fluids.

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We demonstrate conical pores etched in tracked glass chips for fabricating patterns at the micrometer scale. Highly fluorescent patterns based on photopolymerization of diacetylene films were formed by irradiating UV light through conical pores called "photo-pens". The properties of photopens were investigated through experiments, finite-difference-time-domain (FDTD) simulations and numerical calculations based on Fresnel equations.

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