Evaluation of antidiabetic and anti-inflammatory action of selenium nanoparticles mediated through aspalathus linearis - An in vitro study.

Introduction: Selenium nanoparticles (SeNPs) have drawn a lot of interest among researchers because of their distinct impact on antioxidant activity, anti-inflammatory tests, antibacterial activity, and in the treatment of various diseases. A. linearis has shown great findings in biomedical applications because of its physio-chemical compounds such as Aspalathin, orientin, and isoorientin.

In vitro biological evaluation of silver nanoparticles synthesized using zingiber officinale and ocimum gratissimum herbal formulation.

Introduction: The biomedical potential of silver nanoparticles (Ag NPs) synthesized with Zingiber officinale and Ocimum gratissimum herbal formulation was investigated in this study. The study aims to reveal their applications in various biomedical fields. The study evaluates the antioxidant, thrombolytic, and antimicrobial potential of Zingiber officinale and Ocimum gratissimum herbal formulation-mediated Ag NPs.

Anti-diabetic and anti-microbial activity of aspalathus linearis and syzygium aromaticum formulation mediated zinc oxide nanoparticles.

Introduction: Zinc oxide nanoparticles (ZnO NPs) exhibit a wide range of biomedical applications majorly used as antiinflammatory, anti-cancer, anti-diabetic, and anti-microbial activity and other biomedical applications because they show less toxicity and are very compatible. Zinc metal is an inorganic and essential element in the human body at the trace level. ZnO NPs are also GRAS substances (Generally Recognized As Safe).

Ocimum gratissimum mediated synthesis of AgNPs - An in vitro analysis of anti-inflammatory and antimicrobial effects.

Introduction: Silver nanoparticles (AgNPs) are effective against almost all kinds of pathogenic organisms. The green synthesis of AgNPs utilizing extracts from medicinal plants is being researched to examine the therapeutic advantages of AgNPs because the chemical production of AgNPs is more toxic. In this study, the stem extract of Ocimum Gratissimum (OG) also known as Karunthulasi or wild basil for green synthesis of AgNPs and evaluating their antiinflammatory and antimicrobial effects.

COPD Unveiled: Insights from Dwellers along a Busy Highway in Kattankulathur Block.

Background: Chronic obstructive pulmonary disease (COPD) is a serious lung condition that imposes a significant financial burden on individuals and society, straining the medical system. According to the World Health Organization, it was the third leading cause of death worldwide in 2020. In India, it ranks as the second leading cause of death, and in Tamil Nadu, it is the tenth.

Characterisation and serodiagnostic evaluation of a recombinant 22.6-kDa tegument protein of .

Schistosomosis in animals due to significantly burdens India's livestock economy because of high prevalence and morbidity and is mostly underdiagnosed from the lack of sensitive tools for field-level detection. This study aimed to clone, express the 22.6-kDa tegument protein of (rSs22.

A role of fear on diseased food web model with multiple functional response.

In this paper, we analyze the role of fear in a three-species non-delayed ecological model that examines the interactions among susceptible prey, infectious (diseased) prey, and predators within a food web. The prey population grows in a logistic manner until it achieves a carrying capacity, reflecting common population dynamics in the absence of predators. Diseased prey is assumed to transmit infection to healthful prey by the use of a Holling type II reaction.

Antecedents of rapport and its mediating role on relational cohesion in patient-physician interaction.

Increasing competition in healthcare services, it is imperative that physicians and family-care practitioners seek ways to attract and retain patients. Building relationships with existing patients is one sure way to continued patronage and increased clientele. The purpose of this paper is to examine antecedents of rapport and its influence on perceived relationships in the context of patient-physician interaction.

Do nanoparticles delivered to roots affect plant secondary metabolism? A comprehensive analysis in float seedling cultures of Hypericum perforatum L.

Since nanoparticles (NPs) released into the environment from household or industrial wastes and applied directly on plants as agrochemicals can accumulate in the rhizosphere, it is imperative to understand how these NPs affect plant secondary metabolism upon their contact with the roots of intact plants. Here, the effects of Pd, Au, ZnO and FeO NPs on secondary metabolism were comprehensively investigated in Hypericum perforatum L float seedlings by analyzing 41 major secondary metabolites using ultra-performance liquid chromatography coupled with photodiode array, fluorescence detector and high-resolution mass spectrometry (UPLC-PDA-FLR-HRMS). The results showed that exposure of H.

Prediction of Liver Enzyme Elevation Using Supervised Machine Learning in Patients With Rheumatoid Arthritis on Treatment with Methotrexate.

Objective The aim of this study is to develop a machine learning (ML) model to accurately predict liver enzyme elevation in rheumatoid arthritis (RA) patients on treatment with methotrexate (MTX) using electronic health record (EHR) data from a real-world RA cohort. Methods Demographic, clinical, biochemical, and prescription information from 569 RA patients initiated on MTX were collected retrospectively. The primary outcome was the liver transaminase elevation above the upper limit of normal (40 IU/mL), following the initiation of MTX.

COVID-19 Mortality and Remdesivir - A Retrospective Cohort in Intensive Care Setting.

Background: Remdesivir is a broad-spectrum antiviral drug that received emergency use authorization in the first wave of the COVID-19 pandemic. However, its effectiveness in preventing mortality in COVID-19 patients who required intensive care was unclear.

Patients And Methods: We retrospectively analyzed clinical data of 302 patients from intensive care units of a quaternary care center with moderate to severe COVID-19 illness and followed them until discharge between March 2020 and February 2021.

A Case Report of Plasmacytoma in a 28-Year-Old Patient: Bridging the Age Gap in a Rare Presentation.

Plasmacytoma, an uncommon malignancy originating from plasma cells, predominantly manifests in the elderly demographic. However, its incidence among young adults remains infrequent. Herein, we present a case involving a 28-year-old young adult diagnosed with solitary bone plasmacytoma.

COWAVE: A labelled COVID-19 wave dataset for building predictive models.

The ongoing COVID-19 pandemic has posed a significant global challenge to healthcare systems. Every country has seen multiple waves of this disease, placing a considerable strain on healthcare resources. Across the world, the pandemic has motivated diligent data collection, with an enormous amount of data being available in the public domain.

Regulation of Keap1-Nrf2 axis in temporal lobe epilepsy-hippocampal sclerosis patients may limit the seizure outcomes.

Background: Accumulation of reactive oxygen species (ROS) exacerbates neuronal loss during seizure-induced excitotoxicity. Keap1 (Kelch-like ECH-associated protein1)-nuclear factor erythroid 2-related factor 2 (Nrf2) axis is one of the known active antioxidant response mechanisms. Our study focused on finding the factors influencing Keap1-Nrf2 axis regulation in temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) patients.

Maximum Entropy Freeze-Out of Hydrodynamic Fluctuations.

We propose a general approach to freezing out fluctuations in heavy-ion collisions using the principle of maximum entropy. We find the results naturally expressed as a direct relationship between the irreducible relative correlators quantifying the deviations of hydrodynamic as well as hadron gas fluctuations from the ideal hadron gas baseline. The method also allows us to determine heretofore unknown parameters crucial for the freeze-out of fluctuations near the QCD critical point in terms of the QCD equation of state.

Crash Caesarean Delivery: How to Optimise Decision-to-Delivery Interval by Initiating a Novel Code? A Clinical Audit.

Background: Many resource-constrained centres fail to meet the international standard of 30 min of decision-to-delivery interval (DDI) of Category-1 crash caesarean deliveries. However, specific scenarios like acute foetal bradycardia and antepartum haemorrhage necessitate even faster interventions.

Methods: A multidisciplinary team developed a "CODE-10 Crash Caesarean" rapid response protocol to limit DDI to 15 min.

Prevalence of usage of various removable appliances among undergraduate dental students in a private dental college.

The aim of the present study was to assess the prevalence of usage of various removable appliances among undergraduate dental students in private dental colleges. Ethical approval for the study was obtained from the Institutional Review Board of Saveetha Institute of Medical and Technical Sciences, Chennai, India. A dental record of patients was investigated.

"Assisted vaginal birth using the Paily obstetric forceps vs Ventouse - A randomized clinical trial".

Objective: Instruments used in assisted vaginal birth have seen little innovation for decades. Due to the risk of trauma and technical difficulty incurred during forceps delivery, instrumental deliveries are on a decline, and the global rate of primary cesarean birth is rising. The novel Paily Obstetric Forceps (POF) features a compact, lighter design with thinner blades, designed to increase operator comfort and minimize maternal and neonatal injuries.

Managing placenta accreta spectrum in low-resource settings using a novel dissection-free aorta clamp: Operative technique.

Objective: Surgical management of Placenta accreta spectrum (PAS) is associated with profuse bleeding and increased risk of operative injury to the adherent pelvic structures. We propose using a novel aorta clamp that can occlude the abdominal aorta without retroperitoneal dissection, thereby making it easy for an obstetrician-gynecologist to use it. The novel Paily aorta clamp (PAC) is applied just above the bifurcation of the abdominal aorta.

Arresting post-partum hemorrhage using the novel trans-vaginal uterine artery clamp.

Objectives: Post-partum hemorrhage (PPH) continues to be the leading cause of maternal mortality in low-resource settings. The commonest variant - Atonic PPH, is managed by additional pharmacological measures which may fail. Additional surgical interventions for hemostasis take time and are not universally available.

Depletion of Homeostatic Antibodies against Malondialdehyde-Modified Low-Density Lipoprotein Correlates with Adverse Events in Major Vascular Surgery.

We aimed to investigate if major vascular surgery induces LDL oxidation, and whether circulating antibodies against malondialdehyde-modified LDL (MDA-LDL) alter dynamically in this setting. We also questioned relationships between these biomarkers and post-operative cardiovascular events. Major surgery can induce an oxidative stress response.

Telemedicine During the COVID-19 Pandemic: A Paradigm Shift in Non-Communicable Disease Management? - A Cross-Sectional Survey from a Quaternary-Care Center in South India.

Purpose: This study aims to gauge the perception and adoption rates of telemedicine amongst patients with non-communicable diseases (NCD) as opposed to in-person consultations in a quaternary care center in South India.

Patients And Methods: A web-hosted 21-item cross-sectional survey was distributed to 220 randomly selected patients with a routine appointment in one of the seven departments caring for NCDs in the study center. Descriptive analysis and inferential analyses were done.