Publications by authors named "Pradeep K Gunasekaran"
Background: To explore the utility of general movements assessment as a predictive tool of the neurological outcome in term-born infants with hypoxic-ischemic encephalopathy (HIE) at ages six and 12 months.
Methods: This prospective observational study was conducted for 18 months (August 2018 to December 2019). Term-born newborns with HIE were included.
Article Synopsis
- A 9-year-old girl presented with painful swelling in her left index finger, which was punctured, leading to a chronic discharging sinus and other systemic symptoms like lymphadenopathy.
- A Mantoux test confirmed tuberculosis, and a fine aspiration showed signs of inflammation and acid-fast bacilli.
- After being started on a 4-drug antitubercular therapy, she showed significant improvement in pain and swelling within two months, highlighting the condition known as tubercular dactylitis which primarily affects younger children and presents as swelling of tubular bones.
Article Synopsis
- * The condition was attributed to overactivation of parasympathetic pathways, leading to increased acetylcholine release and resultant penile blood flow issues.
- * Despite various treatments to alleviate the condition, including medication and irrigation techniques, the boy required a surgical procedure (distal T-shunt) to resolve the ischemic priapism caused by the scorpion envenomation.
Article Synopsis
- Cornelia de Lange syndrome (CdLS) is a rare developmental disorder marked by unique facial features, skeletal issues, and growth difficulties, with CdLS type 5 (CdLS5) linked to mutations in the HDAC8 gene.
- A case study presents a four-month-old girl with CdLS5 showing unusual symptoms like dystonia, developmental delays, and spastic quadriparesis, alongside a missense mutation in the HDAC8 gene.
- Despite treatment with medication, her symptoms improved only partially by 22 months, contributing to the understanding that CdLS5 can cause isolated dystonia, joining other known genetic disorders.
We discuss an illustrative case of infected scalp abscess with osteomyelitis following a cephalhaematoma in a 19-day-old neonate. Cephalhaematoma is a common occurrence in neonates after prolonged labour, instrument-assisted, and traumatic deliveries and resolves spontaneously in the majority of cases. Infection may follow haematogenous dissemination or direct inoculation via a skin breach.
View Article and Find Full Text PDFObjectives: The profile of seizures in neurocutaneous syndromes is variable. We aimed to define the characteristics of epilepsy in children with neurocutaneous syndromes.
Materials And Methods: Cross-sectional study over 18 months at a tertiary care pediatric hospital, including children with neurocutaneous syndromes aged between 1 and 15 years, using the 2017-International League Against Epilepsy classification.
The genetics of Down syndrome (DS) and Klinefelter syndrome (KS) are a nondisjunction of autosomal and sex chromosomes, respectively, resulting in aneuploidies. Less than 70 cases of concurrent Down-Klinefelter syndrome (DS-KS) have been reported in the literature. We report the case of a five-month-old Indian child with a rare double aneuploidy resulting in DS-KS.
View Article and Find Full Text PDFFamilial hemiplegic migraine (FHM), an autosomal dominant subtype of hemiplegic migraine, is a channelopathy presenting with severe headache, visual field defect, paresthesia, unilateral motor deficit, encephalopathy, seizures and aphasia. This cross-sectional study was conducted over 10 months in children aged 1-18 years suspected of hemiplegic migraine at a tertiary care pediatric hospital. Fourteen children were screened and five children with genetically confirmed FHM were included.
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