GIST (ILEAL) Revealed by Peculiar Paraneoplastic-myositis and Hypo-Thyroidism.

Introduction: To our knowledge this is the first & only case report in India wherein malignant ileal gastrointestinal-stromal-tumor presented with paraneoplastic-myositis & hypothyroidism.

Result: Herein August-2019 IPGMER-SSKM-kolkata 49-year-male laborer presented with 15-days acute onset gradually progressing symmetrical poly-arthralgia (bilateral shoulders & knee) and 10-days acute progressive symmetrical proximal myopathy along-with painfully swollen bilateral thighs and arms (restricted range of motion) besides fatigue for similar duration. absent characteristic skin changes.

Unique Case of Cardiomyopathy Secondary to Adrenal Adenoma (Primary-Aldosteronism).

Introduction: To our knowledge this is the first & only case report in India wherein primary aldosteronism (adrenal adenoma) presented with cardiomyopathy (regressed post-surgery).

Materials: First reported case in India.

Result: Herein August 2018 IPGMER-SSKM-Kolkata 29-year female presented with 1-month exertional dyspnoea, occasional chest pain, sweating, fainting.

Paraneoplastic ANCA positive crescentic glomerulonephritis as presenting feature of Mantle Cell lymphoma a unique case.

Introduction: Mantle Cell Lymphoma is a rare Non-Hodgkin, with unprecedented kidney involvement

Material: case report

Observations: Herein IPGMER-SSKM Kolkata a 57-year-old male presented to us with Low-grade-intermittent fever & B-symptoms of 4months, arthralgia of 3months & oliguria of 10days. Mild pallor, mild hepatosplenomegaly & significant generalized lymphadenopathy. Hemoglobin 8.

Study of Prevalence of Cardiovascular Abnormalities Using ECG & 2D- Echo in Chronic Kidney Disease Patients in Kolkata.

Introduction: Chronic Kidney Disease patients face extraordinary risk for premature death, because of cardiovascular events. This increased risk of CV events may begin during early stages of CKD much before the onset of ESRD. Our study aim was to non-invasively identify prevalence of various asymptomatic cardiovascular abnormalities using ECG & Echo changes in patients with CKD.

Fluorescent pigment and phenol glucosides from the heartwood of Pterocarpus marsupium.

The fluorescence shown by extracts of the heartwood of Pterocarpus marsupium is attributed to salts of the new compound 1, whose structure was elaborated using detailed spectroscopic/spectrometric studies. The plant material also contains the nonfluorescent compounds 2 and 3. The absolute configuration of 1 was determined by experimental and theoretically calculated electronic CD spectra, while that of 3 was deduced from ECD comparison with reported results in the α-hydroxydihydrochalcone series.

A novel galacto-glycerolipid from Oxalis corniculata kills Entamoeba histolytica and Giardia lamblia.

Oxalis corniculata is a naturally occurring weed that has been used in traditional medicine for the cure of dysentery and diarrhea in India. One of the common causes of dysentery is due to infection by the protist pathogen Entamoeba histolytica. Bioactivity profiling of extracts from O.

Effect of fatty acids and cholesterol present in bile on expression of virulence factors and motility of Vibrio cholerae.

Bile induces pleiotropic responses that affect production of virulence factors, motility, and other phenotypes in the enteric pathogen Vibrio cholerae. Since bile is a heterogeneous mixture, crude bile was fractionated, and the components that mediate virulence gene repression and enhancement of motility were identified by nuclear magnetic resonance, gas chromatography (GC), and GC-mass spectrometry analyses. The unsaturated fatty acids detected in bile, arachidonic, linoleic, and oleic acids, drastically repressed expression of the ctxAB and tcpA genes, which encode cholera toxin and the major subunit of the toxin-coregulated pilus, respectively.

Intramolecular nitrone cycloaddition reaction on carbohydrate-based precursors: application in the synthesis of spironucleosides and spirobisnucleosides.

A simple synthesis of chiral spironucleosides and spirobisnucleosides is described. Intramolecular 1,3-dipolar nitrone cycloaddition reaction of d-glucose-derived precursors having olefin at C-3 and nitrone at C-5, C-1, or C-2 (in nor-series) furnished bisisoxazolidinospirocycles 4-7, 11, and 12 in good yields. Reductive ring opening of the isoxazolidine moieties in 4-6 followed by construction of a nucleoside base upon the generated amino groups smoothly yielded spirobisnucleosides 17 and 18 and spironucleosides 20 and 21.