Publications by authors named "Prachi Varshney"

Article Synopsis
  • - PDE5 is an enzyme that breaks down cGMP, a molecule crucial for enhancing neural signals and influencing learning and memory processes, and it's found in the brain and in the smooth muscle of the corpus cavernosum.
  • - PDE5 inhibitors, which prevent the breakdown of cGMP, can enhance nitric oxide effects, providing anti-inflammatory and neuroprotective benefits, potentially addressing neurodegenerative disorders, which currently lack curative treatments.
  • - The review explores how PDE5 inhibitors may act as disease-modifying agents for conditions like Alzheimer's and Parkinson's diseases by simultaneously influencing both cAMP and cGMP pathways, potentially improving neurological functions.
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Neurological disorders are devastating conditions affecting both cognitive and motorrelated functions in aged people. Yet there is no proper medication to treat these illnesses, and the currently available medications can only provide symptomatic relief to the patients. All neurological disorders share the same etiology, such as oxidative stress, mitochondrial dysfunction, neurochemical deficiency, neuronal loss, apoptosis, endoplasmic reticulum stress, neuroinflammation, and disease-related protein aggregation.

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The novel bovine viral infection known as lumpy skin disease is common in most African and Middle Eastern countries, with a significant likelihood of disease transfer to Asia and Europe. Recent rapid disease spread in formerly disease-free zones highlights the need of understanding disease limits and distribution mechanisms. Capripox virus, the causal agent, may also cause sheeppox and Goatpox.

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Background: Cancer drug resistance remains a difficult barrier to effective treatment, necessitating a thorough understanding of its multi-layered mechanism.

Objective: This study aims to comprehensively explore the diverse mechanisms of cancer drug resistance, assess the evolution of resistance detection methods, and identify strategies for overcoming this challenge. The evolution of resistance detection methods and identification strategies for overcoming the challenge.

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Catalytic water splitting is a highly promising area of research for the development of a hydrogen-based society. Herein, the synthesis of the bifunctional AB-type cobalt(iii) corrole Co(BAPC)Py having the electron-withdrawing meso-pentafluorophenyl and the basic meso-p-aminophenyl substituents is reported. Cyclic voltammetric studies reveal that Co(BAPC)Py has two oxidation waves at 0.

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Micro-algae have potential as sustainable sources of energy and products and alternative mode of agriculture. However, their mass cultivation is challenging due to low survival under harsh outdoor conditions and competition from other, undesired, species. Extremophilic micro-algae have a role to play by virtue of their ability to grow under acidic or alkaline pH, high temperature, light, CO2 level and metal concentration.

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